Evidence map›Paper›PMID 38201656›Full record

ArticleCancers2024

Ninjurin 2, a Cell Adhesion Molecule and a Target of p53, Modulates Wild-Type p53 in Growth Suppression and Mutant p53 in Growth Promotion.

Jin Zhang, Xiangmudong Kong, Hee Jung Yang, Shakur Mohibi, Christopher August Lucchesi, Weici Zhang, Xinbin Chen

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jin ZhangComparative Oncology Laboratory, The University of California, Davis, CA 95616, USA.
Xiangmudong KongComparative Oncology Laboratory, The University of California, Davis, CA 95616, USA.
Hee Jung YangComparative Oncology Laboratory, The University of California, Davis, CA 95616, USA.
Shakur MohibiComparative Oncology Laboratory, The University of California, Davis, CA 95616, USA.ORCID 0000-0001-5539-0841
Christopher August LucchesiComparative Oncology Laboratory, The University of California, Davis, CA 95616, USA.ORCID 0000-0001-8767-7003
Weici ZhangDivision of Rheumatology, Allergy and Clinical Immunology, The University of California, Davis, CA 95616, USA.
Xinbin ChenComparative Oncology Laboratory, The University of California, Davis, CA 95616, USA.ORCID 0000-0002-4582-6506
University of California, Davis · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
Mechanism of p53-dependent Tumor SuppressionR01CA250338 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 2020 to 2024
$2.2M
The Mechanism and Therapeutic Potential of Targeting the Ninjurin Pathway for Tumors Carrying Wild-Type p53R01CA272753 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Xinbin Chen · 2022 to 2026
$2.2M
PPHF 2014: IMMUNIZATION CAPACITY BUILDING FOR INFRASTRUCTURE ENHANCEMENTS TO MEET INTEROPERABILITY REQUIREMENTS IN RHODE ISLANDU38IP000886 · IP · RHODE ISLAND STATE DEPT OF HEALTH · PI AMORE, ELLEN · 2014 to 2014
$712k
NCI NIH HHS CA093373NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA250338NCI NIH HHS R01 CA272753NCIRD CDC HHS U38 IP000886NIH HHS CA272753
6 · The paper itself

Abstract

The nerve injury-induced protein 1 (NINJ1) and NINJ2 constitute a family of homophilic adhesion molecules and are involved in nerve regeneration. Previously, we showed that NINJ1 and p53 are mutually regulated and the NINJ1-p53 loop plays a critical role in p53-dependent tumor suppression. However, the biology of NINJ2 has not been well-explored. By using multiple in vitro cell lines and genetically engineered mouse embryo fibroblasts (MEFs), we showed that

Indexed as

cell proliferationcellular senescenceNINJ2p53

Identifiers

PMID38201656
PMCPMC10778559
OpenAlexW4390586533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.