Evidence map›Paper›PMID 38201650›Full record

ArticleCancers2024

Aspirin and Cancer Survival: An Analysis of Molecular Mechanisms.

Manoj Pandey, Monika Rajput, Pooja Singh, Mridula Shukla, Bin Zhu, Jill Koshiol

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Manoj PandeyDepartment of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.ORCID 0000-0002-1496-9846
Monika RajputDepartment of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.ORCID 0000-0002-4601-9175
Pooja SinghDepartment of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Mridula ShuklaRRL, Dr. Lalpath Labs Ltd., Shivpur, Varanasi 221003, India.
Bin ZhuDivision of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), 9609 Medical Center Drive, RM 6-E212, Rockville, MD 20850, USA.
Jill KoshiolDivision of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), 9609 Medical Center Drive, RM 6-E212, Rockville, MD 20850, USA.ORCID 0000-0002-3832-6204
Institute of Medical Sciences · INNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The benefit of aspirin on cancer survival is debated. Data from randomized clinical trials and cohort studies are discordant, although a meta-analysis shows a clear survival advantage when aspirin is added to the standard of care. However, the mechanism by which aspirin improves cancer survival is not clear. A PubMed search was carried out to identify articles reporting genes and pathways that are associated with aspirin and cancer survival. Gene ontology and pathway enrichment analysis was carried out using web-based tools. Gene-gene and protein-protein interactions were evaluated. Crosstalk between pathways was identified and plotted. Forty-one genes were identified and classified into primary genes (

Indexed as

aspirincancer survivalCOX2genesmechanismpathwayproteins

Identifiers

PMID38201650
PMCPMC10778469
OpenAlexW4390543793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.