Evidence map›Paper›PMID 38201549›Full record

ArticleCancers2023

Lymphovascular Invasion at the Time of Radical Prostatectomy Adversely Impacts Oncological Outcomes.

Niranjan J Sathianathen, Marc A Furrer, Clancy J Mulholland, Andreas Katsios, Christopher Soliman, Nathan Lawrentschuk, Justin S Peters, Homi Zargar, Anthony J Costello, Christopher M Hovens and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Niranjan J SathianathenDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.ORCID 0000-0002-3710-014X
Marc A FurrerDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.
Clancy J MulhollandDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.
Andreas KatsiosDepartment of Urology, University of Bern, 3010 Bern, Switzerland.
Christopher SolimanDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.
Nathan LawrentschukDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.ORCID 0000-0001-8553-5618
Justin S PetersDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.
Homi ZargarDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.
Anthony J CostelloDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.
Christopher M HovensEpworth Healthcare, Melbourne, VIC 3121, Australia.
Conrad BishopEpworth Healthcare, Melbourne, VIC 3121, Australia.
Ranjit RaoDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.
Raymond TongDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.
Daniel SteinerEpworth Healthcare, Melbourne, VIC 3121, Australia.
Daniel MoonDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.
Benjamin C ThomasDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.
Philip DundeeDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.ORCID 0000-0002-8581-5051
Jose Antonio Rodriguez CaleroInstitute of Pathology, University of Bern, 3010 Bern, Switzerland.
George N ThalmannDepartment of Urology, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-1908-3286
Niall M CorcoranDepartment of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3050, Australia.ORCID 0000-0003-4483-6945
The Royal Melbourne Hospital · AUUniversity of Bern · CHProstate Cancer Foundation of Australia · AUEpworth Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphovascular invasion, whereby tumour cells or cell clusters are identified in the lumen of lymphatic or blood vessels, is thought to be an essential step in disease dissemination. It has been established as an independent negative prognostic indicator in a range of cancers. We therefore aimed to assess the impact of lymphovascular invasion at the time of prostatectomy on oncological outcomes. We performed a multicentre, retrospective cohort study of 3495 men who underwent radical prostatectomy for localised prostate cancer. Only men with negative preoperative staging were included. We assessed the relationship between lymphovascular invasion and adverse pathological features using multivariable logistic regression models. Kaplan-Meier curves and Cox proportional hazard models were created to evaluate the impact of lymphovascular invasion on oncological outcomes. Lymphovascular invasion was identified in 19% (

Indexed as

lymphovascular invasionoutcomes researchprostate cancerprostatectomyprostate surgery

Identifiers

PMID38201549
PMCPMC10778356
OpenAlexW4390231710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.