Evidence map›Paper›PMID 38201536›Full record

ArticleCancers2023

Technical and Clinical Outcomes of Laparoscopic-Laparotomic Hepatocellular Carcinoma Thermal Ablation with Microwave Technology: Case Series and Review of Literature.

Riccardo Muglia, Paolo Marra, Domenico Pinelli, Ludovico Dulcetta, Francesco Saverio Carbone, Alessandro Barbaro, Antonio Celestino, Michele Colledan, Sandro Sironi

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Riccardo MugliaDepartment of Radiology, Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.ORCID 0000-0003-0092-5065
Paolo MarraDepartment of Radiology, Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.ORCID 0000-0003-4935-8110
Domenico PinelliDepartment of General Surgery, Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.
Ludovico DulcettaDepartment of Radiology, Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.ORCID 0000-0002-6991-2046
Francesco Saverio CarboneDepartment of Radiology, Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.ORCID 0000-0003-0507-2874
Alessandro BarbaroSchool of Medicine, University of Milano-Bicocca, 20126 Milano, Italy.
Antonio CelestinoSchool of Medicine, University of Milano-Bicocca, 20126 Milano, Italy.ORCID 0009-0008-4072-3402
Michele ColledanDepartment of General Surgery, Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.
Sandro SironiDepartment of Radiology, Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate technical and clinical outcomes of intraoperative (laparoscopic/laparotomic) microwave ablation on HCC. MATERIALS AND

methodsThis is a retrospective single-center study evaluating consecutive patients treated for very early/early-stage HCC with intraoperative microwave ablation from 1 July 2017 to 30 June 2023. In these patients, a percutaneous US-guided approach was excluded due to the nodule's suboptimal visibility or harmful location and liver resection for a deep position or adherences. Data about the clinical stage, surgical approach, liver pathology and nodules characteristics, technical success, complications, and follow-up were collected. Technical success was intended as the absence of locoregional persistence at follow-up CT/MRI controls.

resultsA total of 36 cirrhotic patients (M:F = 30:6, median age 67 years) were enrolled; 18/36 (50%) had a single nodule, 13/36 (36%) had two, 4/36 had three (11%), and 1/36 had four (3%). Among the patients, 24 (67%) were treated with laparoscopy, and 12/36 (33%) with a laparotomic approach. Sixty HCCs of 16.5 mm (6-50 mm) were treated for 7 min (2-30 min) with 100 W of power. A total of 55 nodules (92%) were treated successfully and showed no residual enhancement at the first postoperative follow-up; the other 5/60 (8%) underwent chemo/radioembolization. There was one complication (3%): a biliary fistula treated with percutaneous drainage and glue embolization. The average hospital stay was 3.5 days (1-51 days), and patients were followed up on average for 238 days (13-1792 days). During follow-up, 5/36 patients (14%) underwent liver transplantation, 1/36 (2%) died during hospitalization and 1 after discharge.

conclusionsLaparoscopic/laparotomic intraoperative HCC MW ablation is feasible in patients unsuitable for percutaneous approach or hepatic resection, with rare complications and with good technical and clinical outcomes.

Indexed as

hepatocellular carcinomalaparoscopylaparotomymicrowave ablationthermal ablation

Identifiers

PMID38201536
PMCPMC10778313

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.