Evidence map›Paper›PMID 38201431›Full record

ArticleCancers2023

Digging into the NGS Information from a Large-Scale South European Population with Metastatic/Unresectable Pancreatic Ductal Adenocarcinoma: A Real-World Genomic Depiction.

Dimitrios C Ziogas, Eirini Papadopoulou, Helen Gogas, Stratigoula Sakellariou, Evangellos Felekouras, Charalampos Theocharopoulos, Dimitra T Stefanou, Maria Theochari, Ioannis Boukovinas, Dimitris Matthaios and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. GSK3βGut · 2026
    Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Dimitrios C ZiogasFirst Department of Internal Medicine, Laikon General Hospital, School of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-2620-4004
Eirini PapadopoulouGeneKor Medical S.A., 15344 Gerakas, Greece.
Helen GogasFirst Department of Internal Medicine, Laikon General Hospital, School of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-0451-2885
Stratigoula SakellariouFirst Department of Pathology, School of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Evangellos FelekourasFirst Department of Surgery, Laikon General Hospital, School of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Charalampos TheocharopoulosFirst Department of Internal Medicine, Laikon General Hospital, School of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Dimitra T StefanouFirst Department of Internal Medicine, Laikon General Hospital, School of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Maria TheochariFirst Department of Internal Medicine, Laikon General Hospital, School of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Ioannis BoukovinasDepartment of Medical Oncology, Bioclinic Hospital, 54622 Thessaloniki, Greece.
Dimitris MatthaiosOncology Department, General Hospital of Rhodes, 85133 Rhodes, Greece.
Anna KoumarianouHematology Oncology Unit, Fourth Department of Internal Medicine, School of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-4159-2511
Eleni ZairiOncology Department, St. Lukes Hospital, 55236 Thessaloniki, Greece.
Michalis LiontosDepartment of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0001-7192-4575
Konstantinos KoutsoukosDepartment of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Vasiliki Metaxa-MariatouGeneKor Medical S.A., 15344 Gerakas, Greece.
George KapetsisGeneKor Medical S.A., 15344 Gerakas, Greece.
Angeliki MeintaniGeneKor Medical S.A., 15344 Gerakas, Greece.
Georgios N TsaousisGeneKor Medical S.A., 15344 Gerakas, Greece.ORCID 0000-0002-8975-8779
George NasioulasGeneKor Medical S.A., 15344 Gerakas, Greece.
National and Kapodistrian University of Athens · GRAthens Medical Center · GRGeneral Hospital of Rhodes · GRPolyclinic General Hospital · GRSt. Luke's Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite ongoing oncological advances, pancreatic ductal adenocarcinoma (PDAC) continues to have an extremely poor prognosis with limited targeted and immunotherapeutic options. Its genomic background has not been fully characterized yet in large-scale populations all over the world. Methods: Replicating a recent study from China, we collected tissue samples from consecutive Greek patients with pathologically-confirmed metastatic/unresectable PDAC and retrospectively investigated their genomic landscape using next generation sequencing (NGS). Findings: From a cohort of 409 patients, NGS analysis was successfully achieved in 400 cases (56.50% males, median age: 61.8 years). Consistent with a previous study,

Indexed as

genomic mutationHRRKRASnext generation sequencingpancreatic ductal adenocarcinoma

Identifiers

PMID38201431
PMCPMC10778112
OpenAlexW4389950222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.