Evidence map›Paper›PMID 38201359›Full record

ArticleDiagnostics (Basel, Switzerland)2023

The Assessment of Serum Fibronectin Levels as a Potential Biomarker for the Severity of Drug-Sensitive Pulmonary Tuberculosis: A Pilot Study.

Shreedhar Kulkarni, Sumalatha Arunachala, Sindaghatta Krishnarao Chaya, Rekha Vaddarahalli ShankaraSetty, Medha Karnik, Nidhi Bansal, Sukanya Ravindran, Komarla Sundararaja Lokesh, Mikash Mohan, Mohammed Kaleem Ullah and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Shreedhar KulkarniDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.ORCID 0009-0009-0147-8376
Sumalatha ArunachalaDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.ORCID 0000-0001-5858-8298
Sindaghatta Krishnarao ChayaDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.ORCID 0000-0002-4898-9466
Rekha Vaddarahalli ShankaraSettyDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.ORCID 0009-0008-6781-3627
Medha KarnikCentre for Excellence in Molecular Biology and Regenerative Medicine (A DST-FIST Supported Center), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.
Nidhi BansalDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.
Sukanya RavindranDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.ORCID 0009-0002-6507-8098
Komarla Sundararaja LokeshDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.ORCID 0000-0001-5651-1123
Mikash MohanDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.
Mohammed Kaleem UllahCentre for Excellence in Molecular Biology and Regenerative Medicine (A DST-FIST Supported Center), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.ORCID 0000-0001-8470-3114
Jayaraj Biligere SiddaiahDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.
Padukudru Anand MaheshDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570015, India.ORCID 0000-0003-1632-5945
JSS Academy of Higher Education and Research · IN

Funding

Research Training at the Confluence of Infectious and Non-Communicable Diseases in IndiaD43TW010332 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI COX, JEFFERY S · 2017 to 2022
$836k
FIC NIH HHS D43 TW010332
6 · The paper itself

Abstract

backgroundTuberculosis (TB) is a global health burden caused by

methodsNewly detected consecutive sputum AFB-positive pulmonary TB patients (

resultsThe PTB patients showed lower Fn levels (102.4 ± 26.7) compared with the controls (108.8 ± 6.8), but they were not statistically significant. Higher AFB smear grades had lower Fn levels. The chest X-ray zones involved were inversely correlated with Fn levels. The Fn levels, adjusted for age and gender, decreased with increased mycobacterial load and the number of chest radiograph zones affected. A Fn level <109.39 g/mL predicted greater TB severity (sensitivity of 67.57% and specificity of 90.38%), while a level <99.32 pg/mL predicted severity based on the chest radiology (sensitivity of 84.21% and specificity of 100%).

conclusionsThe Fn levels are lower in tuberculosis patients and are negatively correlated with severity based on sputum mycobacterial load and chest radiographs. The Fn levels may serve as a potential biomarker for assessing TB severity, which could have implications for early diagnosis and treatment monitoring.

Indexed as

disease severityfibronectinmycobacterial loadMycobacterium tuberculosissputum positive PTB

Identifiers

PMID38201359
PMCPMC10804257
OpenAlexW4390231264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.