Evidence map›Paper›PMID 38201268›Full record

ReviewCells2023

Advancements in Cell-Based Therapies for HIV Cure.

Yusuke Matsui, Yasuo Miura

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Advanced Therapies for Human Immunodeficiency Virus.Medical sciences (Basel, Switzerland) · 2024
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Yusuke MatsuiGladstone Institute of Virology, Gladstone Institutes, 1650 Owens St., San Francisco, CA 941578, USA.
Yasuo MiuraDepartment of Transfusion Medicine and Cell Therapy, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake, Toyoake 470-1192, Aichi, Japan.ORCID 0000-0001-9654-1300
Fujita Health University Hospital · JPGladstone Institutes · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of human immunodeficiency virus (HIV-1) has evolved since the establishment of combination antiretroviral therapy (ART) in the 1990s, providing HIV-infected individuals with approaches that suppress viral replication, prevent acquired immunodeficiency syndrome (AIDS) throughout their lifetime with continuous therapy, and halt HIV transmission. However, despite the success of these regimens, the global HIV epidemic persists, prompting a comprehensive exploration of potential strategies for an HIV cure. Here, we offer a consolidated overview of cell-based therapies for HIV-1, focusing on CAR-T cell approaches, gene editing, and immune modulation. Persistent challenges, including CAR-T cell susceptibility to HIV infection, stability, and viral reservoir control, underscore the need for continued research. This review synthesizes current knowledge, highlighting the potential of cellular therapies to address persistent challenges in the pursuit of an HIV cure.

Indexed as

Acquired Immunodeficiency SyndromeHIV InfectionsAntiretroviral Therapy, Highly ActiveCell- and Tissue-Based TherapyHIVHumansAIDSBerlin PatientCAR-T cellCCR5CD34+ cellCD4+ T cellclinical trialscombination ARTCRISPR/Cas9cure studycytokine release syndromecytotoxic T lymphocyteelite controllerfunctional cureHIV-1latencylatency-reversing agentsoff-the-shelf

Identifiers

PMID38201268
PMCPMC10778010
OpenAlexW4390347493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.