Evidence map›Paper›PMID 38201264›Full record

ArticleCells2023

Fecal Supernatants from Patients with Crohn's Disease Induce Inflammatory Alterations in M2 Macrophages and Fibroblasts.

Frida Gorreja, Mia Bendix, Stephen T A Rush, Lujain Maasfeh, Otto Savolainen, Anders Dige, Jorgen Agnholt, Lena Öhman, Maria K Magnusson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Frida GorrejaDepartment of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0000-0003-3548-4618
Mia BendixMedical Department, Randers Regional Hospital, 8930 Randers, Denmark.
Stephen T A RushDepartment of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Lujain MaasfehDepartment of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0000-0003-2944-5700
Otto SavolainenChalmers Mass Spectrometry Infrastructure, Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
Anders DigeDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, 8200 Aarhus, Denmark.
Jorgen AgnholtDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, 8200 Aarhus, Denmark.
Lena ÖhmanDepartment of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0000-0001-8142-2106
Maria K MagnussonDepartment of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0000-0002-8888-4968
University of Gothenburg · SEAarhus University Hospital · DKChalmers University of Technology · SERegional Hospital Randers · DK

Funding

Adlerbertska Foundations 2020/751Apotekare Hedberg Stiftelse 2022Region Västra Götaland VGFOUREG-931919 and VGFOUREG-940815Swedish government and the county councils; the ALF-agreement ALFGBG-723921 and ALFGBG-965619Swedish Research Council 2019-01052Wilhelm & Martina Lundgrens Stiftelser 2022-3970
6 · The paper itself

Abstract

Intestinal macrophages and fibroblasts act as microenvironmental sentinels mediating inflammation and disease progression in Crohn's disease (CD). We aimed to establish the effects of fecal supernatants (FSs) from patients with CD on macrophage and fibroblast phenotype and function. FS were obtained by ultracentrifugation, and the metabolites were analyzed. Monocyte-derived M2 macrophages and fibroblasts were conditioned with FS, and secreted proteins, surface proteins and gene expression were analyzed. M2 macrophage efferocytosis was evaluated. Patients with CD (

Indexed as

Crohn DiseaseCulture Media, ConditionedDisease ProgressionFibroblastsHumansInflammationCulture Media, ConditionedCrohn’s diseasefecal metabolitesfibrosisinflammatory bowel diseaseM2 macrophages

Identifiers

PMID38201264
PMCPMC10777926
OpenAlexW4390274637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.