Evidence map›Paper›PMID 38201240›Full record

ArticleCells2023

The Cysteine Protease Legumain Is Upregulated by Vitamin D and Is a Regulator of Vitamin D Metabolism in Mice.

Karl Martin Forbord, Meshail Okla, Ngoc Nguyen Lunde, Tatjana Bosnjak-Olsen, Guro Arnekleiv, Daniel Hesselson, Harald Thidemann Johansen, Jonathan C Y Tang, Moustapha Kassem, Rigmor Solberg and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 5 countries.

Karl Martin ForbordSection for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
Meshail OklaDepartment of Endocrinology and Metabolism, Odense University Hospital, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0003-4855-243X
Ngoc Nguyen LundeSection for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
Tatjana Bosnjak-OlsenSection for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
Guro ArnekleivSection for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
Daniel HesselsonCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-8675-9426
Harald Thidemann JohansenSection for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
Jonathan C Y TangBioanalytical Facility, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.ORCID 0000-0001-6305-6333
Moustapha KassemDepartment of Endocrinology and Metabolism, Odense University Hospital, University of Southern Denmark, 5230 Odense, Denmark.
Rigmor SolbergSection for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.ORCID 0000-0001-7205-4401
Abbas JafariDepartment of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.ORCID 0000-0003-2443-6231
University of Oslo · NOUniversity of Copenhagen · DKUniversity of Southern Denmark · DKThe University of Sydney · AUUniversity of East Anglia · GB

Funding

Olav Thon (Norway) No grant number
6 · The paper itself

Abstract

Legumain is a lysosomal cysteine protease that has been implicated in an increasing amount of physiological and pathophysiological processes. However, the upstream mechanisms regulating the expression and function of legumain are not well understood. Here, we provide in vitro and in vivo data showing that vitamin D

Indexed as

Cysteine ProteasesVitamin DAnimalsAsparaginyl EndopeptidaseCysteine EndopeptidasesHumansMiceVitaminsAsparaginyl EndopeptidaseCysteine EndopeptidasesCysteine ProteasesVitamin DVitaminsasparaginyl endopeptidaselegumainmetabolismproteolysisvitamin D

Identifiers

PMID38201240
PMCPMC10778535
OpenAlexW4390174814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.