Evidence map›Paper›PMID 38200547›Full record

ArticlePediatric blood & cancer2024

Experiences and outcomes of fertility testing in male adolescents with sickle cell disease.

Susan Creary, Sophia M Liles, Zachary A Colton, Charis J Stanek, Matthew C Hudnall, Gwendolyn P Quinn, Leena Nahata

Open access · bronzeAbstract read
In one paragraph

Article in Pediatric blood & cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Susan CrearyAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0002-4730-8139
Sophia M LilesAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
Zachary A ColtonAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0002-1065-6092
Charis J StanekAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
Matthew C HudnallReproducitve Diagnostics, Inc., Columbus, Ohio, USA.
Gwendolyn P QuinnDepartment of Obstetrics and Gynecology, NYU Grossman School of Medicine, New York City, New York, USA.
Leena NahataAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0003-3899-2642
Nationwide Children's Hospital · USDNA Diagnostics Center (United States) · USNew York University · US

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
Optimizing fertility preservation and decision quality in male AYA with cancer: A family-centered interventionK08CA237338 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI NAHATA, LEENA · 2019 to 2023
$1.0M
NCATS NIH HHS UL1 TR002733NCI NIH HHS K08 CA237338
6 · The paper itself

Abstract

Adult males with sickle cell disease (SCD) may have abnormal semen parameters, raising the concern that SCD and/or treatments may impact fertility. Yet, studies that include adolescents are lacking. To determine if fertility testing is feasible in male adolescents with SCD, and to explore their experiences and outcomes of fertility testing, 33 adolescents who completed a web-based SCD reproductive health education program were offered a free semen analysis. Five (15%) obtained testing and each had abnormalities. Barriers to testing included lack of time and transportation and discomfort. Findings highlight the need for larger, longitudinal studies using innovative testing approaches.

Indexed as

Anemia, Sickle CellAdolescentAdultFertilityHumansLongitudinal StudiesMalefertility testingmale adolescentssickle cell disease

Identifiers

PMID38200547
PMCPMC10922962
OpenAlexW4390743001

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.