Evidence map›Paper›PMID 38200498›Full record

Observational studyJournal of translational medicine2024

Sex-differences in Mediterranean diet: a key piece to explain sex-related cardiovascular risk in obesity? A cross-sectional study.

Luigi Barrea, Ludovica Verde, Rosario Suárez, Evelyn Frias-Toral, Celina Andrade Vásquez, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06661330 (Exploring Gender Differences in the Effects of Diet and Physical Activity on Metabolic Parameters), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06661330 completednot on this map

Exploring Gender Differences in the Effects of Diet and Physical Activity on Metabolic Parameters

TypeobservationalSponsorSan Raffaele Telematic UniversityRan2024 to 2024Enrolled200ConditionsDiet Therapy, Mediterranean Diet, Body Composition Changes, Physical ActivityArmsBehavioral Treatment
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luigi Barrea *Dipartimento di Scienze Umanistiche, Università Telematica Pegaso, Via Porzio, Centro Direzionale, isola F2, 80143, Naples, Italy. luigi.barrea@unipegaso.it.ORCID 0000-0001-9054-456X
Ludovica Verde *Unità di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Centro Italiano per la cura e il Benessere del Paziente con Obesità (C.I.B.O), Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.
Rosario SuárezSchool of Medicine, Universidad Técnica Particular de Loja, Calle París, San Cayetano Alto, Loja, 110107, Ecuador.
Evelyn Frias-ToralSchool of Medicine, Universidad Católica Santiago de Guayaquil, Av. Pdte. Carlos Julio Arosemena Tola, Guayaquil, 090615, Ecuador.
Celina Andrade VásquezSchool of Medicine, Universidad Técnica Particular de Loja, Calle París, San Cayetano Alto, Loja, 110107, Ecuador.
Annamaria ColaoUnità di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Centro Italiano per la cura e il Benessere del Paziente con Obesità (C.I.B.O), Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.
Silvia SavastanoUnità di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Centro Italiano per la cura e il Benessere del Paziente con Obesità (C.I.B.O), Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.
Giovanna MuscogiuriUnità di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Centro Italiano per la cura e il Benessere del Paziente con Obesità (C.I.B.O), Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131, Naples, Italy. giovanna.muscogiuri@unina.it.ORCID 0000-0002-8809-4931

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMediterranean Diet (MD) has many health benefits, particularly in reducing cardiovascular risk (CVR). However, it is still little known if there are any sex differences in following this nutritional pattern and, thus, the potential sex-related repercussions on CVR in obesity. The study aimed to characterize sex-related adherence to MD and its association with CVR factors in subjects with obesity.

methodsA total of 968 females (33.81 ± 11.06 years; BMI 34.14 ± 7.43 kg/m

resultsFemales had significantly higher adherence to MD and lower hs-CRP levels than males (p < 0.001). Additionally, females consumed significantly more vegetables, fruits, legumes, fish/seafood, nuts, and sofrito sauce and less quantity of olive oil, butter, cream, margarine, red/processed meats, soda drinks (p = 0.001), red wine, and commercial sweets and confectionery than their counterparts. A PREDIMED score of ≤ 6 was associated with a significantly increased CVR in both sexes.

conclusionsFemales had higher adherence to MD, lower CVR, and different food preferences than males. Although the same PREDIMED threshold has been identified as a spy of CVR, the sex-related preference of individual foods included in the MD could explain the different impact of this nutritional pattern on CVR in both sexes.

Indexed as

Cardiovascular DiseasesDiet, MediterraneanAdultC-Reactive ProteinCross-Sectional StudiesFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedObesityRisk FactorsSex CharacteristicsYoung AdultC-Reactive ProteinCardiovascular riskDietGenderHigh sensitivity C reactive proteinMediterranean dietNutritionObesitySex differences

Identifiers

PMID38200498
PMCPMC10782790

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.