Evidence map›Paper›PMID 38200493›Full record

ArticleBMC pulmonary medicine2024

Clinical characteristics and mortality predictors among very old patients with pulmonary thromboembolism: a multicenter study report.

Xia Zhou, Yuanhua Yang, Zhenguo Zhai, Dingyi Wang, Jieping Lei, Xiaomao Xu, Yingqun Ji, Qun Yi, Hong Chen, Xiaoyun Hu and 17 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 11 institutions in 1 country.

Xia ZhouShijingshan Teaching Hospital of Capital Medical University, Shijingshan Hospital, Capital Medical University, BeijingBeijing, China.
Yuanhua YangDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. yyh1031@sina.com.
Zhenguo ZhaiNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China. zhaizhenguo2011@126.com.
Dingyi WangNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
Jieping LeiNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
Xiaomao XuDepartment of Pulmonary and Critical Care Medicine, Beijing Hospital, Beijing, China.
Yingqun JiDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Qun YiDepartment of Pulmonary and Critical Care Medicine, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Hong ChenDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiaoyun HuDepartment of Pulmonary and Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.
Zhihong LiuFuwai Hospital, Chinese Academy of Medical Science, National Center for Cardiovascular Diseases, Beijing, China.
Yimin MaoDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
Jie ZhangDepartment of Pulmonary and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China.
Juhong ShiDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Beijing, China.
Zhu ZhangNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
Sinan WuNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
Qian GaoNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
Xincao TaoNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
Wanmu XieNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
Jun WanNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
Yunxia ZhangNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
Shuai ZhangNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
Kaiyuan ZhenNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
Zhonghe ZhangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Baomin FangDepartment of Pulmonary and Critical Care Medicine, Beijing Hospital, Beijing, China.
Chen WangNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, China.
China pUlmonary thromboembolism REgistry Study (CURES) investigators
Chinese Academy of Medical Sciences & Peking Union Medical College · CNCapital Medical University · CNChina-Japan Friendship Hospital · CNBeijing Hospital · CNDalian Medical University · CNPeking University · CNFirst Affiliated Hospital of Henan University of Science and Technology · CNShanxi Medical University · CNSecond Affiliated Hospital of Jilin University · CNBeijing Chao-Yang Hospital, Capital Medical University · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CN

Funding

the China Key Research Projects of the 12th National Five-Year Development Plan 2011BA11B17
6 · The paper itself

Abstract

backgroundClinical characteristics of patients with pulmonary thromboembolism have been described in previous studies. Although very old patients with pulmonary thromboembolism are a special group based on comorbidities and age, they do not receive special attention.

objectiveThis study aims to explore the clinical characteristics and mortality predictors among very old patients with pulmonary thromboembolism in a relatively large population. DESIGN AND

participantsThe study included a total of 7438 patients from a national, multicenter, registry study, the China pUlmonary thromboembolism REgistry Study (CURES). Consecutive patients with acute pulmonary thromboembolism were enrolled and were divided into three groups. Comparisons were performed between these three groups in terms of clinical characteristics, comorbidities and in-hospital prognosis. Mortality predictors were analyzed in very old patients with pulmonary embolism. KEY

resultsIn 7,438 patients with acute pulmonary thromboembolism, 609 patients aged equal to or greater than 80 years (male 354 (58.1%)). There were 2743 patients aged between 65 and 79 years (male 1313 (48%)) and 4095 patients aged younger than 65 years (male 2272 (55.5%)). Patients with advanced age had significantly more comorbidities and worse condition, however, some predisposing factors were more obvious in younger patients with pulmonary thromboembolism. PaO2 < 60 mmHg, eGFR < 60 mL/min/1.73m2, malignancy, anticoagulation as first therapy were mortality predictors for all-cause death in very old patients with pulmonary thromboembolism. The analysis found that younger patients were more likely to have chest pain, hemoptysis (the difference was statistically significant) and dyspnea triad.

conclusionIn very old population diagnosed with pulmonary thromboembolism, worse laboratory results, atypical symptoms and physical signs were common. Mortality was very high and comorbid conditions were their features compared to younger patients. PaO2 < 60 mmHg, eGFR < 60 mL/min/1.73m2 and malignancy were positive mortality predictors for all-cause death in very old patients with pulmonary thromboembolism while anticoagulation as first therapy was negative mortality predictors.

Indexed as

NeoplasmsPulmonary EmbolismAgedAnticoagulantsBlood Gas AnalysisFemaleHumansMaleOxygenAnticoagulantsOxygenMortalityOldPulmonary thromboembolism

Identifiers

PMID38200493
PMCPMC10782748
OpenAlexW4390707758

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