Evidence map›Paper›PMID 38200453›Full record

ArticleBMC pediatrics2024

Congenital cytomegalovirus infection in newborns suspected of congenital rubella syndrome in Iran: a cross-sectional study.

Negar Mirsalehi, Jila Yavarian, Nastaran Ghavami, Maryam Naseri, Farshad Khodakhah, Somayeh Shatizadeh Malekshahi, Sevrin Zadheidar, Talat Mokhtari-Azad, Nazanin-Zahra Shafiei-Jandaghi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Negar MirsalehiVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Jila YavarianVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Nastaran GhavamiVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Maryam NaseriVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Farshad KhodakhahVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Somayeh Shatizadeh MalekshahiDepartment of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Sevrin ZadheidarVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Talat Mokhtari-AzadVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Nazanin-Zahra Shafiei-JandaghiVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Nz-shafiei@tums.ac.ir.
Tehran University of Medical Sciences · IRTarbiat Modares University · IR

Funding

Tehran University of Medical Sciences and Health Services 97-03-27-38669
6 · The paper itself

Abstract

backgroundFollowing rubella virus control, the most important cause of congenital infections is human cytomegalovirus (HCMV). Congenital CMV (cCMV) may happen both in primary and non-primary maternal infections. The present study aimed to screen cCMV in symptomatic newborns suspected of congenital rubella syndrome (CRS) in Iran.

methodsOut of 1629 collected infants' serum samples suspected of CRS but negative for rubella IgM, 524 samples were selected regarding cCMV complications. These samples were divided into two age groups: 1- one month and younger, 2- older than 1 month up to one year. Anti-HCMV IgM detection was performed on these serums. Then HCMV IgG avidity assay and HCMV DNA detection were carried out on all samples with positive and borderline results in IgM detection.

resultsHerein, 3.67% of symptomatic infants aged one month and younger had positive and borderline HCMV IgM, 12.5% of which had a low avidity index (AI). HCMV IgM detection rate among symptomatic infants older than one month to one year was 14.5%. Identified genotypes in this study were gB-1(63.63%), gB2 (18.18%), and gB3 (18.18%), respectively.

conclusionsThis comprehensive study was performed on serum samples of symptomatic infants clinically suspected of cCMV from all over Iran. There was a good correlation between serology findings and PCR.

Indexed as

Cytomegalovirus InfectionsRubella Syndrome, CongenitalAntibodies, ViralCross-Sectional StudiesHumansImmunoglobulin MInfantInfant, NewbornIranAntibodies, ViralImmunoglobulin MAvidity assayCongenital rubella syndromeGenotypeHuman cytomegalovirus

Identifiers

PMID38200453
PMCPMC10777647
OpenAlexW4390699287

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.