Evidence map›Paper›PMID 38200385›Full record

ArticleAnnals of surgical oncology2024

Prognostic Importance of Lymphovascular Invasion for Specific Subgroup of Patients with Prostate Cancer After Robot-Assisted Radical Prostatectomy (The MSUG94 Group).

Makoto Kawase, Shin Ebara, Tomoyuki Tatenuma, Takeshi Sasaki, Yoshinori Ikehata, Akinori Nakayama, Masahiro Toide, Tatsuaki Yoneda, Kazushige Sakaguchi, Jun Teishima and 7 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Makoto KawaseDepartment of Urology, Gifu University Graduate School of Medicine, Gifu, Japan.
Shin EbaraDepartment of Urology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Tomoyuki TatenumaDepartment of Urology, Yokohama City University, Yokohama, Japan.
Takeshi SasakiDepartment of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Tsu, Japan.
Yoshinori IkehataDepartment of Urology, University of Toyama, Toyama, Japan.
Akinori NakayamaDepartment of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan.
Masahiro ToideDepartment of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Tatsuaki YonedaDepartment of Urology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Kazushige SakaguchiDepartment of Urology, Toranomon Hospital, Tokyo, Japan.
Jun TeishimaDepartment of Urology, Kobe City Hospital Organization, Kobe City Medical Center West Hospital, Kobe, Japan.
Kazuhide MakiyamaDepartment of Urology, Yokohama City University, Yokohama, Japan.
Takahiro InoueDepartment of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Tsu, Japan.
Hiroshi KitamuraDepartment of Urology, University of Toyama, Toyama, Japan.
Kazutaka SaitoDepartment of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan.
Fumitaka KogaDepartment of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Shinji UrakamiDepartment of Urology, Toranomon Hospital, Tokyo, Japan.
Takuya KoieDepartment of Urology, Gifu University Graduate School of Medicine, Gifu, Japan. koie.takuya.h2@f.gifu-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate whether lymphovascular invasion (LVI) was associated with oncological outcomes in patients with prostate cancer (PCa) undergoing robotic-assisted radical prostatectomy (RARP).

methodsThis retrospective multicenter cohort study was conducted on 3195 patients with PCa who underwent RARP in nine institutions in Japan. The primary endpoints were the associations between biochemical recurrence (BCR) and LVI and between BCR and clinicopathological covariates, while the secondary endpoints were the association between LVI and the site of clinical recurrence and metastasis-free survival (MFS).

resultsIn total, 2608 patients met the inclusion criteria. At the end of the follow-up period, 311 patients (11.9%) were diagnosed with BCR and none died of PCa. In patients with pathological stage T2 (pT2) + negative resection margins (RM-), and pT3+ positive RM (RM+), LVI significantly worsened BCR-free survival (BRFS). For patients with PCa who had pT3 and RM+, the 2-year BRFS rate in those with LVI was significantly worse than in those without LVI. Patients with LVI had significantly worse MFS than those without LVI with respect to pT3, RM+, and pathological Gleason grade (pGG). In multivariate analysis, LVI was significantly associated with BRFS in patients with pT3 PCa, and with worse MFS in PCa patients with pT3, RM+, and pGG ≥ 4.

conclusionsLVI was an independent prognostic factor for recurrence and metastasis after RARP, particularly in patients with pT3 and RM+ PCa. Locally advanced PCa with positive LVI and RM+ requires careful follow-up because of the high likelihood of recurrence.

Indexed as

Prostatic NeoplasmsRoboticsRobotic Surgical ProceduresCohort StudiesHumansMalePrognosisProstatectomyRetrospective StudiesLocally advanced prostate cancerLymphovascular invasionProstate cancerRobot-assisted radical prostatectomy

Identifiers

PMID38200385

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.