ReviewAnnals of intensive care2024
The critically ill older patient with sepsis: a narrative review.
Review in Annals of intensive care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The safety, acceptability, and effectiveness of home-based 'exercise snacking' for improving physical function of older adults: a systematic review.European geriatric medicine · 2026Pooled it
- Influence of early enteral nutrition on mortality of adult patients with sepsis: a meta-analysis of randomized controlled trials.European journal of medical research · 2025Pooled it
- Impact of sarcopenia and frailty on outcomes of patients with sepsis or septic shock: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Aging-caused the changes of the gut microbiota drive intestinal barrier dysfunction and increase sepsis susceptibility.Gut microbes · 2026Article
- Cognitive Health and Quality of Life After Surviving Sepsis: A Narrative Review.Journal of intensive care medicine · 2026Review
- Association between early body temperature dynamic trajectory and mortality and infection rates for patients with cardiac arrest in ICU: a retrospective study.Journal of thoracic disease · 2026Article
- Clinically recognized sepsis in older adults admitted to medical wards: patient characteristics and hospital outcomes from the REPOSI register.Internal and emergency medicine · 2026Article
- Prognostic value of C-reactive protein to albumin ratio (CAR) for mortality in older adults with sepsis: Cohort study.Clinical medicine (London, England) · 2026Article
- Factors associated with mortality in older sepsis patients: a nationwide retrospective cohort study in Germany.Age and ageing · 2026Observational
- Trends in mortality from cancer and sepsis in the United States, 1999 to 2023: An analysis of CDC WONDER data.Medicine · 2026Article
- Temporal Trends in the Chronobiology and Epidemiology of Sepsis Admissions over 21 Years: A Nationwide Study in Northwestern Spain.Antibiotics (Basel, Switzerland) · 2026Article
- Age- and Sex-Related Outcomes in Patients with Sepsis or Septic Shock: A Prospective Monocentric Cohort Study.Journal of clinical medicine · 2026Article
- First-week absolute lymphocyte count dynamics and 28-day mortality in older adults with sepsis.BMC infectious diseases · 2026Article
- The Relationship Between the Pan-Immune-Inflammation Value (PIV) and Mortality in Elderly Critically Ill Patients with Sepsis: A Single-Centre Retrospective Study.Journal of clinical medicine · 2026Article
- Sepsis in Frail Older Adults: Tailored Antimicrobial Stewardship and Individualized Care Approach.Antibiotics (Basel, Switzerland) · 2026Review
- Age-related differences and common pathways of lymphocyte subsets in sepsis: a comparative review of elderly and pediatric patients.Cell death & disease · 2026Review
- Comorbidities, Routine Biomarkers and Early Septic Shock Occurrence in Patients with Sepsis: A Retrospective Longitudinal Study.Diagnostics (Basel, Switzerland) · 2026Article
- Elderly patients with healthcare-associated infections in the emergency department: clinical characteristics and risk factors for septic shock: a retrospective study.BMC geriatrics · 2026Article
- Prognostic Value of Nutritional Risk Scores in Septic ICU Patients: A Survival Analysis Using mNUTRIC, PNI, and CONUT.Diagnostics (Basel, Switzerland) · 2026Article
- Pre-illness Clonal Hematopoiesis of Indeterminate Potential is an Independent Predictor of Morbidity and Mortality in Sepsis.medRxiv : the preprint server for health sciences · 2026Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a significant public health concern, particularly affecting individuals above 70 years in developed countries. This is a crucial fact due to the increasing aging population, their heightened vulnerability to sepsis, and the associated high mortality rates. However, the morbidity and long-term outcomes are even more notable. While many patients respond well to timely and appropriate interventions, it is imperative to enhance efforts in identifying, documenting, preventing, and treating sepsis. Managing sepsis in older patients poses greater challenges and necessitates a comprehensive understanding of predisposing factors and a heightened suspicion for diagnosing infections and assessing the risk of sudden deterioration into sepsis. Despite age often being considered an independent risk factor for mortality and morbidity, recent research emphasizes the pivotal roles of frailty, disease severity, and comorbid conditions in influencing health outcomes. In addition, it is important to inquire about the patient's preferences and establish a personalized treatment plan that considers their potential for recovery with quality of life and functional outcomes. This review provides a summary of the most crucial aspects to consider when dealing with an old critically ill patient with sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.