ArticleNature2024
Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 1 pooled it
70.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Prevalence of autoimmune diseases is strongly associated with average annual temperatures: systematic review and linear regression analysis.BMC rheumatology · 2025Pooled it
- Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026Review
- Genetic Risk in Multiple Sclerosis: Susceptibility, Modifiers and Unresolved Questions.Neurology and therapy · 2026Review
- CAR-T Cell Therapy and Gut Microbiota Modulation in Multiple Sclerosis: Emerging Therapeutic Strategies and Current Limitations.Current issues in molecular biology · 2026Review
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- Local ancestry inference identifies robust evidence of selection in Neolithic Europe.Molecular biology and evolution · 2026Article
- Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans.Nature ecology & evolution · 2026Article
- Neurodegenerative diseases and immune system: From pathogenic mechanism to therapy.Neural regeneration research · 2026Article
- Genetic basis of Asian diabetes.Journal of diabetes investigation · 2026Review
- Ancient genomics study reveals low HLA diversity in eastern hunter-gatherers.Genome biology · 2026Article
- High-coverage paleo-genome research identifies a pathogenic mutation on EXT1 in a Qing-period Chinese individual with multiple osteochondromas.Molecular genetics and genomics : MGG · 2026Article
- DCIR-mediated inhibitory regulation of TLR7-MyD88 axis prevents autoimmune neuroinflammation.iScience · 2026Article
- Article
- Insights into human adaptation from ancient DNA.Nature genetics · 2026Review
- Insights into infectious diseases through ancient pathogen genomics.Nature reviews. Microbiology · 2026Review
- Demyelinating disorders in women: epidemiology, immunology, and clinical implications across MS, NMOSD, and MOGAD.Journal of neurology · 2026Review
- Leveraging Kinase Drugs for Neurosciences: Discovery of Selective, CNS-Penetrant Reversible Bruton's Tyrosine Kinase Inhibitors as Therapeutics for Neuroinflammation.Journal of medicinal chemistry · 2026Article
- Article
- Temporal shifts in polygenic traits track major epidemics in Western Eurasia.bioRxiv : the preprint server for biology · 2026Article
- Graph transformer for ancient ancestry inference.bioRxiv : the preprint server for biology · 2026Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 8 institutions in 7 countries.
William Barrie *Department of Zoology, University of Cambridge, Cambridge, UK.
Yaoling Yang *Department of Statistical Sciences, School of Mathematics, University of Bristol, Bristol, UK.ORCID 0000-0003-4905-8097
Evan K Irving-Pease *Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-1940-2192
Kathrine E Attfield *Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID 0000-0003-3387-521X
Gabriele Scorrano *Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0887-4023
Lise Torp Jensen *Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Angelos P ArmenOxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Evangelos Antonios DimopoulosPathogen Genomics and Evolution Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Aaron SternDepartments of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA, USA.
Alba Refoyo-MartinezLundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
Alice PearsonDepartment of Genetics, University of Cambridge, Cambridge, UK.
Abigail RamsøeLundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
Charleen GaunitzLundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
Fabrice DemeterLundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
Marie Louise S JørkovLaboratory of Biological Anthropology, Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-5283-4328
Stig Bermann MøllerÅlborg Historiske Museum, Nordjyske Museer, Vestbjerg, Denmark.
Bente SpringborgÅlborg Historiske Museum, Nordjyske Museer, Vestbjerg, Denmark.
Lutz KlassenMuseum Østdanmark-Djursland og Randers, Randers, Denmark.
Inger Marie HyldgårdMuseum Østdanmark-Djursland og Randers, Randers, Denmark.
Niels WickmannMuseum Vestsjælland, Holbæk, Denmark.
Lasse VinnerLundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
Thorfinn Sand KorneliussenLundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-7576-5380
Morten E AllentoftLundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
Martin SikoraLundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2818-8319
Kristian KristiansenLundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
Santiago RodriguezMRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.
Rasmus NielsenLundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0513-6591
Astrid K N IversenOxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK. astrid.iversen@ndcn.ox.ac.uk.ORCID 0000-0002-3507-5956
Daniel J LawsonDepartment of Statistical Sciences, School of Mathematics, University of Bristol, Bristol, UK. dan.lawson@bristol.ac.uk.ORCID 0000-0002-5311-6213
Lars FuggerOxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK. lars.fugger@ndcn.ox.ac.uk.ORCID 0000-0003-2883-3226
Eske WillerslevDepartment of Zoology, University of Cambridge, Cambridge, UK. ew482@cam.ac.uk.ORCID 0000-0002-7081-6748
University of Copenhagen · DKJohn Radcliffe Hospital · GBUniversity of Bristol · GBUniversity of Cambridge · GBAarhus University Hospital · DKRegional Hospital Randers · DKUniversity of Bremen · DEUniversity of California, Berkeley · US
Funding
Enabling Precision Genomics Using Adaptive VariationR01GM138634 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NIELSEN, RASMUS · 2020 to 2023
$1.7MMedical Research Council MC_UU_00036/3NIGMS NIH HHS R01 GM138634Wellcome Trust
Abstract
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated
Indexed as
Genetic Predisposition to DiseaseGenome, HumanGrasslandMultiple SclerosisDatasets as TopicDietEuropeGenetics, MedicalHistory, 15th CenturyHistory, AncientHistory, MedievalHuman MigrationHumansLife StyleNeurodegenerative DiseasesPopulation Density
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.