ReviewMolecular psychiatry2024
Psychosis superspectrum I: Nosology, etiology, and lifespan development.
Review in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Auditory event-related potentials and psychosis dimensions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study.Molecular psychiatry · 2026Article
- Neural Responses to Reward and Psychosis Dimensions.Schizophrenia bulletin · 2026Article
- The neurodevelopmental spectrum: phenotypic architecture, etiology, predictive utility, and specificity across development.Molecular psychiatry · 2026Article
- Environmental risk score as a predictor for 25-year symptom and functional trajectories in first episode psychosis.medRxiv : the preprint server for health sciences · 2026Article
- From neuroinflammation to neural inference: computational psychiatry meets precision medicine.Schizophrenia (Heidelberg, Germany) · 2026Review
- Schizophrenia.Nature reviews. Disease primers · 2025Review
- Where is mania in the meta-structure of psychopathology?Psychological medicine · 2025Article
- Three Distinct Pathways to First Episode Mania and Psychosis: Latent Class Analysis of Antecedent Psychopathology.Acta psychiatrica Scandinavica · 2025Article
- Polygenic Scores for Schizophrenia and Educational Attainment Predict Global Functioning Across Psychiatric Hospitalization Among People with Schizophrenia.medRxiv : the preprint server for health sciences · 2025Article
- Developmental perspectives on HiTOP psychosis superspectrum: Unveiling pitfalls and theoretical fallacies.Frontiers in psychiatry · 2025Article
- Article
- 'Whole-Body' Perspectives of Schizophrenia and Related Psychotic Illness: miRNA-143 as an Exemplary Molecule Implicated across Multi-System Dysfunctions.Biomolecules · 2024Review
- Treatment of Cognitive Impairment Associated with Schizophrenia Spectrum Disorders: New Evidence, Challenges, and Future Perspectives.Brain sciences · 2024Review
- Psychosis superspectrum II: neurobiology, treatment, and implications.Molecular psychiatry · 2024Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
This review describes the Hierarchical Taxonomy of Psychopathology (HiTOP) model of psychosis-related psychopathology, the psychosis superspectrum. The HiTOP psychosis superspectrum was developed to address shortcomings of traditional diagnoses for psychotic disorders and related conditions including low reliability, arbitrary boundaries between psychopathology and normality, high symptom co-occurrence, and heterogeneity within diagnostic categories. The psychosis superspectrum is a transdiagnostic dimensional model comprising two spectra-psychoticism and detachment-which are in turn broken down into fourteen narrow components, and two auxiliary domains-cognition and functional impairment. The structure of the spectra and their components are shown to parallel the genetic structure of psychosis and related traits. Psychoticism and detachment have distinct patterns of association with urbanicity, migrant and ethnic minority status, childhood adversity, and cannabis use. The superspectrum also provides a useful model for describing the emergence and course of psychosis, as components of the superspectrum are relatively stable over time. Changes in psychoticism predict the onset of psychosis-related psychopathology, whereas changes in detachment and cognition define later course. Implications of the superspectrum for genetic, socio-environmental, and longitudinal research are discussed. A companion review focuses on neurobiology, treatment response, and clinical utility of the superspectrum, and future research directions.
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