Evidence map›Paper›PMID 38200162›Full record

ArticleThe Journal of antibiotics2024

Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10-13.

Di Mao, Pengwei Yu, Naoya Shinzato, Lei Zhang, Weiping Zheng, Shan Lu, Hideaki Kakeya

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Di MaoSchool of Pharmacy, Jiangsu University, Zhenjiang, 212013, China.
Pengwei YuSchool of Pharmacy, Jiangsu University, Zhenjiang, 212013, China.
Naoya ShinzatoTropical Biosphere Research Center, University of the Ryukyus, Okinawa, 903-0213, Japan.
Lei ZhangDepartment of System Chemotherapy and Molecular Sciences, Division of Medicinal Frontier Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan.
Weiping ZhengSchool of Pharmacy, Jiangsu University, Zhenjiang, 212013, China.
Shan LuSchool of Pharmacy, Jiangsu University, Zhenjiang, 212013, China. lushan@ujs.edu.cn.
Hideaki KakeyaDepartment of System Chemotherapy and Molecular Sciences, Division of Medicinal Frontier Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan. scseigyo-hisyo@pharm.kyoto-u.ac.jp.ORCID 0000-0002-4293-7331

Funding

University of the Ryukyus 19SP07101
6 · The paper itself

Abstract

A novel antibiotic biosynthetic precursor of cezomycin, named precezomycin (1), was isolated from culture broth of actinomycete Kitasatospora putterlickiae 10-13. The planar structure was determined by 1D/2D NMR and HR(ESI)MS data analyses, and the absolute configurations were established by TDDFT calculation of ECD spectra. Precezomycin (1) exhibited moderate antibacterial activity against gram-positive bacteria including Staphylococcus aureus and Bacillus subtilis. The discovery of 1 extends the natural product family of cezomycin and provides a new insight into understanding the biosynthetic process of these polyether ionophore metabolites.

Indexed as

ActinobacteriaStreptomycesStreptomycetaceaeAnti-Bacterial AgentsCalcimycinMicrobial Sensitivity TestsMolecular StructureAnti-Bacterial AgentsCalcimycincezomycin

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.