ArticleTranslational psychiatry2024
Targeting suicidal ideation in major depressive disorder with MRI-navigated Stanford accelerated intelligent neuromodulation therapy.
Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Subcallosal cingulate functional connectivity in depression: a systematic review of brain stimulation-induced changes and pretreatment connectivity predictors.Translational psychiatry · 2026Pooled it
- Neurophysiological biomarkers of treatment response in suicidal ideation: a systematic review.Translational psychiatry · 2025Pooled it
- Transcranial magnetic stimulation in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of cortical excitability and therapeutic efficacy.Frontiers in psychiatry · 2025Pooled it
- Dual-Site aiTBS for Suicidal Ideation in Adolescents With Major Depressive Disorder: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Intermittent theta-burst stimulation with adjunctive D-cycloserine rapidly resolves suicidal ideation and decreases implicit association with death/suicide.Psychological medicine · 2025Trial
- Neural markers of working memory and emotional regulation are predictors of future depression severity in at risk young adults: a replication study.Molecular psychiatry · 2026Article
- Efficacy of Personalized Connectivity-Guided Accelerated Brain Stimulation in a Naturalistic Treatment-Resistant Depression Population.medRxiv : the preprint server for health sciences · 2026Article
- The applications of TMS in brain function assessment and treatment of mental disorders: a narrative review.Frontiers in psychiatry · 2026Review
- A Study on dynamic functional connectivity and efficacy prediction of SAINT for rapid antidepressant effects and relief of suicidal ideation.Translational psychiatry · 2025Article
- Disruptions in Cognitive-Affective Circuitry in Major Depression Disorder: Insights From REST-Meta-MDD and Its Implication for Predicting TMS Treatment Efficacy.CNS neuroscience & therapeutics · 2025Article
- Exploring the capabilities of repetitive transcranial magnetic stimulation in major depressive disorder: Dynamic causal modeling of the neural network.Translational psychiatry · 2025Article
- The Effectiveness of Transcranial Magnetic Stimulation in Suicidality: An Updated Systematic Review.medRxiv : the preprint server for health sciences · 2025Article
- Consensus review and considerations on TMS to treat depression: A comprehensive update endorsed by the National Network of Depression Centers, the Clinical TMS Society, and the International Federation of Clinical Neurophysiology.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Review
- Rapid treatment center for depression in China: constructive reflections and transnational implications.Frontiers in psychiatry · 2025Review
- Repetitive transcranial magnetic stimulation enhanced by neuronavigation in the treatment of depressive disorder and schizophrenia.World journal of psychiatry · 2024Article
- Network-based near-scalp personalized brain stimulation targets.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 3 countries.
Funding
Abstract
High suicide risk represents a serious problem in patients with major depressive disorder (MDD), yet treatment options that could safely and rapidly ameliorate suicidal ideation remain elusive. Here, we tested the feasibility and preliminary efficacy of the Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) in reducing suicidal ideation in patients with MDD. Thirty-two MDD patients with moderate to severe suicidal ideation participated in the current study. Suicidal ideation and depression symptoms were assessed before and after 5 days of open-label SAINT. The neural pathways supporting rapid-acting antidepressant and suicide prevention effects were identified with dynamic causal modelling based on resting-state functional magnetic resonance imaging. We found that 5 days of SAINT effectively alleviated suicidal ideation in patients with MDD with a high response rate of 65.63%. Moreover, the response rates achieved 78.13% and 90.63% with 2 weeks and 4 weeks after SAINT, respectively. In addition, we found that the suicide prevention effects of SAINT were associated with the effective connectivity involving the insula and hippocampus, while the antidepressant effects were related to connections of the subgenual anterior cingulate cortex (sgACC). These results show that SAINT is a rapid-acting and effective way to reduce suicidal ideation. Our findings further suggest that distinct neural mechanisms may contribute to the rapid-acting effects on the relief of suicidal ideation and depression, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.