Trial reportBMJ mental health2024
A chatbot to improve adherence to internet-based cognitive-behavioural therapy among workers with subthreshold depression: a randomised controlled trial.
Trial report in BMJ mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Therapeutic Interaction Features of AI Chatbots in Depression Interventions: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Smartphone CBT engagement and depressive symptoms: secondary analysis of the RESiLIENT trial using a time-varying exposure approach.Psychological medicine · 2026Trial
- Assessing the Efficacy of the INTELLECT Cognitive Behavioral Therapy Mobile App for Anxiety and Depressive Symptoms Among At-Risk Japanese Employees: Randomized Controlled Trial.JMIR mHealth and uHealth · 2025Trial
- Cultural Prompting Improves the Empathy and Cultural Responsiveness of GPT-Generated Therapy Responses.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Trial
- A clinically actionable framework for personalizing iCBT to improve depression outcomes.NPJ digital medicine · 2026Review
- Effectiveness of AI and rule-based conversational agents for depression, anxiety and stress: A meta-analysis.NPJ digital medicine · 2026Article
- Conversational AI and Personal Growth: Insights from a Critical Integrative Review.Behavioral sciences (Basel, Switzerland) · 2026Review
- Systematic review and meta analysis of chatbots in the management of depressive and anxiety symptoms.NPJ digital medicine · 2026Article
- Improving adherence to an online intervention for low mood by a virtual coach or personalized motivational feedback messages: A three-arm pilot randomized controlled trial.Internet interventions · 2026Article
- Understanding Adolescents' Perceived Barriers to Engagement in Online Cognitive Behaviour Therapy Programs for Anxiety and Their Ideas for Enhancing User Experience.Journal of clinical psychology · 2025Article
- Charting the evolution of artificial intelligence mental health chatbots from rule-based systems to large language models: a systematic review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Practitioner Perspectives on the Uses of Generative AI Chatbots in Mental Health Care: Mixed Methods Study.JMIR human factors · 2025Article
- Engagement With an Internet-Administered, Guided, Low-Intensity Cognitive Behavioral Therapy Intervention for Parents of Children Treated for Cancer: Analysis of Log-Data From the ENGAGE Feasibility Trial.JMIR formative research · 2025Article
- Exploring user characteristics, motives, and expectations and the therapeutic alliance in the mental health conversational AI Clare®: a baseline study.Frontiers in digital health · 2025Article
- Alter egos alter engagement: perspective-taking can improve disclosure quantity and depth to AI chatbots in promoting mental wellbeing.Frontiers in digital health · 2025Article
- Too good to be true? Exploring the role of artificial intelligence chatbots in treating depression and anxiety.Proceedings (Baylor University. Medical Center)Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInternet-based cognitive-behavioural therapy (iCBT) is effective for subthreshold depression. However, iCBT has problems with adherence, especially when unaccompanied by human guidance. Knowledge on how to enhance adherence to iCBT without human involvement can contribute to improving the effectiveness of iCBT.
objectiveThis is an implementation study to examine the effect of an automated chatbot to improve the adherence rate of iCBT.
methodsWe developed a chatbot to increase adherence to an existing iCBT programme, and a randomised controlled trial was conducted with two groups: one group using iCBT plus chatbot (iCBT+chatbot group) and one group not using the chatbot (iCBT group). Participants were full-time employees with subthreshold depression working in Japan (n=149, age mean=41.4 (SD=11.1)). The primary endpoint was the completion rate of the iCBT programme at 8 weeks.
findingsWe analysed data from 142 participants for the primary outcome. The completion rate of the iCBT+chatbot group was 34.8% (24/69, 95% CI 23.5 to 46.0), that of the iCBT group was 19.2% (14/73, 95% CI 10.2 to 28.2), and the risk ratio was 1.81 (95% CI 1.02 to 3.21).
conclusionsCombining iCBT with a chatbot increased participants' iCBT completion rate. CLINICAL IMPLICATIONS: Encouraging messages from the chatbot could improve participation in an iCBT programme. Further studies are needed to investigate whether chatbots can improve adherence to the programme in the long term and to assess their impact on depression, anxiety and well-being. TRIAL REGISTRATION NUMBER: UMIN000047621.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.