ArticleBMJ (Clinical research ed.)2024
Perinatal depression and risk of mortality: nationwide, register based study in Sweden.
Article in BMJ (Clinical research ed.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Cost Effectiveness of Interventions for Perinatal Anxiety and/or Depression: A Systematic Review of Global Evidence.Applied health economics and health policy · 2026Pooled it
- Combined healthy lifestyle factors and psychosocial outcomes among cancer survivors: a systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2026Pooled it
- Prevalence of postpartum depression in the COVID-19 pandemic and associated factors: systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Different psychological interventions for perinatal depression: a systematic review and meta-analysis of randomized controlled trials.BMC psychiatry · 2025Pooled it
- Leveraging artificial intelligence in the prediction, diagnosis and treatment of depression and anxiety among perinatal women in low- and middle-income countries: a systematic review.BMJ mental health · 2025Pooled it
- Identifying and synthesizing components of perinatal mental health peer support - a systematic review.Frontiers in psychiatry · 2024Pooled it
- Association of Cognitive Function With Event-Related Potentials and Immune Inflammation in Adolescents With Major Depressive Disorder.Brain and behavior · 2026Article
- Consequences of Maternal Antidepressant and Anticonvulsant Use During Pregnancy: Is Postnatal Inpatient Monitoring Required? - A Retrospective Cohort Study.Geburtshilfe und Frauenheilkunde · 2026Article
- Circulating Endothelial Nitric Oxide Synthase on the First Postpartum Day: An Exploratory Cross-Sectional Study of Its Association with Maternal Age, Redox-Relevant Haematological and Lipid Markers, and Postnatal Depression Screening.Antioxidants (Basel, Switzerland) · 2026Article
- Time-varying restless legs syndrome and risk of incident perinatal depression.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Shared Genetic Architecture of Premenstrual Disorder and Postpartum Depression: Registry-Based and Genetic Evidence.Research square · 2026Article
- Article
- Physiological Mechanisms in Pregnancy and Their Relevance to the Clinical Management of Perinatal Mental Illness.Journal of clinical medicine · 2026Review
- Patient perspectives on barriers to rTMS for peripartum depression.BMC psychiatry · 2026Article
- Advances in Perinatal Depression: A Focus on Screening and Treatment.Journal of clinical medicine · 2026Review
- Preconception and early-pregnancy exposure to ambient air pollution and trajectories of depressive symptoms during pregnancy.Environmental health : a global access science source · 2026Article
- The role of serum oxytocin levels in the third trimester of pregnancy in the incidence of postpartum depressive symptoms.Scientific reports · 2026Article
- Maternal psychiatric disorders before, during, and after pregnancy: a national cohort study in Sweden.Molecular psychiatry · 2026Article
- Prenatal depression exposure and infant developmental outcomes: a retrospective cohort study of reduced fetal growth indicators, elevated neonatal heart rate, and developmental trajectories in China.Frontiers in psychiatry · 2026Article
- Perinatal depression management: A narrative review of guidelines and recommendations in chosen European countries.European journal of midwifery · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether women with perinatal depression are at an increased risk of death compared with women who did not develop the disorder, and compared with full sisters.
designNationwide, register based study.
settingSwedish national registers, 1 January 2001 to 31 December 2018.
participants86 551 women with a first ever diagnosis of perinatal depression ascertained through specialised care and use of antidepressants, and 865 510 women who did not have perinatal depression were identified and matched based on age and calendar year at delivery. To address familial confounding factors, comparisons were made between 270 586 full sisters (women with perinatal depression (n=24 473) and full sisters who did not have this disorder (n=246 113)), who gave at least one singleton birth during the study period.
main outcome measuresPrimary outcome was death due to any cause. Secondary outcome was cause specific deaths (ie, unnatural and natural causes). Multivariable Cox regression was used to estimate hazard ratios of mortality comparing women with perinatal depression to unaffected women and sisters, taking into account several confounders. The temporal patterns of perinatal depression and differences between antepartum and postpartum onset of perinatal depression were also studied.
results522 deaths (0.82 per 1000 person years) were reported among women with perinatal depression diagnosed at a median age of 31.0 years (interquartile range 27.0 to 35.0) over up to 18 years of follow-up. Compared with women who did not have perinatal depression, women with perinatal depression were associated with an increased risk of death (adjusted hazard ratio 2.11 (95% confidence interval 1.86 to 2.40)); similar associations were reported among women who had and did not have pre-existing psychiatric disorder. Risk of death seemed to be increased for postpartum than for antepartum depression (hazard ratio 2.71 (95% confidence interval 2.26 to 3.26)
conclusionsEven when accounting for familial factors, women with clinically diagnosed perinatal depression were associated with an increased risk of death, particularly during the first year after diagnosis and because of suicide. Women who are affected, their families, and health professionals should be aware of these severe health hazards after perinatal depression.
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