Trial reportBMJ open2024
Older adults' attitudes towards deprescribing and medication changes: a longitudinal sub-study of a cluster randomised controlled trial.
Trial report in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03724539 (Optimizing PharmacoTherapy In the Multimorbid Elderly in Primary CAre), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing PharmacoTherapy In the Multimorbid Elderly in Primary CAre: a Cluster Randomized Controlled Trial (the OPTICA Trial)
Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Challenges and possibilities of enabling person-centred engagement in medication safety with older people living at home.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2026Article
- Exploring the association between intention and action in deprescribing.Journal of the American Geriatrics Society · 2025Article
- Older Adults' Attitudes Toward Deprescribing in 14 Countries.JAMA network open · 2025Article
- Latent Class Analysis Identifies Four Distinct Patient Deprescribing Typologies Among Older Adults in Four Countries.Innovation in aging · 2025Article
- Low-value practices in primary care: a cross-sectional study comparing data between males and females in Spain.BMJ open · 2024Observational
- Exploring GP and patient attitudes towards the use and deprescribing of dietary supplements: a survey study in Switzerland.BMC primary care · 2024Article
- Healthcare provider-related perceptions toward deprescribing inappropriate medications among older adult outpatients.PloS one · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between older patients' willingness to have one or more medications deprescribed and: (1) change in medications, (2) change in the appropriateness of medications and (3) implementation of prescribing recommendations generated by the electronic decision support system tested in the 'Optimising PharmacoTherapy In the Multimorbid Elderly in Primary CAre' (OPTICA) trial.
designA longitudinal sub-study of the OPTICA trial, a cluster randomised controlled trial.
settingSwiss primary care settings.
participantsParticipants were aged ≥65 years, with ≥3 chronic conditions and ≥5 regular medications recruited from 43 general practitioner (GP) practices. EXPOSURES: Patients' willingness to have medications deprescribed was assessed using three questions from the 'revised Patient Attitudes Towards Deprescribing' (rPATD) questionnaire and its concerns about stopping score. MEASURES/ANALYSES: Medication-related outcomes were collected at 1 year follow-up. Aim 1 outcome: change in the number of long-term medications between baseline and 12 month follow-up. Aim 2 outcome: change in medication appropriateness (Medication Appropriateness Index). Aim 3 outcome: binary variable on whether any prescribing recommendation generated during the OPTICA medication review was implemented. We used multilevel linear regression analyses (aim 1 and aim 2) and multilevel logistic regression analyses (aim 3). Models were adjusted for sociodemographic variables and the clustering effect at GP level.
results298 patients completed the rPATD, 45% were women and 78 years was the median age. A statistically significant association was found between the concerns about stopping score and the change in the number of medications over time (per 1-unit increase in the score the average number of medications use was 0.65 higher; 95% CI: 0.08 to 1.22). Other than that we did not find evidence for statistically significant associations between patients' agreement with deprescribing and medication-related outcomes.
conclusionsWe did not find evidence for an association between most measures of patient agreement with deprescribing and medication-related outcomes over 1 year. TRIAL REGISTRATION NUMBER: NCT03724539.
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