ArticleJournal of the mechanical behavior of biomedical materials2024
Material properties of nonpregnant and pregnant human uterine layers.
Article in Journal of the mechanical behavior of biomedical materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Exploring Spatial Patterning of Endothelial Cells and Trophoblast Cells in a Microfluidic Device.Tissue engineering. Part A · 2026Article
- A finite element model of pregnancy derived from maternal sonography: effect of uterine and cervical structural properties on cervical mechanical loading.bioRxiv : the preprint server for biology · 2026Article
- Reactive oxygen species accelerated glycation for oxygen-independent corneal cross-linking.Frontiers in bioengineering and biotechnology · 2026Article
- The Role of Biomechanical Regulation in Physiological and Pathological Pregnancy: From Mechanotransduction to Clinical Implications.International journal of biological sciences · 2026Review
- Maternal age and parity influences on health outcomes: a multivariable regression analysis of mothers and infants.BMC pregnancy and childbirth · 2025Article
- Modeling Uterine Fibroids Using Bioengineered Hydrogels.ACS biomaterials science & engineering · 2025Article
- Article
- Time-dependent material properties and composition of the nonhuman primate uterine layers through gestation.Scientific reports · 2025Article
- Bioengineering approaches for patient-specific analysis of placenta structure and function.Placenta · 2025Article
- Biomechanical and Compositional Changes in the Murine Uterus with Age.Annals of biomedical engineering · 2025Article
- Time-Dependent Material Properties and Composition of the Nonhuman Primate Uterine Layers Through Gestation.bioRxiv : the preprint server for biology · 2025Article
- Equilibrium mechanical properties of the human uterus in tension and compression.Acta biomaterialia · 2025Article
- A Brief Introductory Guide to Nanoindentation for Comparative and Evolutionary Biologists, with a Case Study of Bone Material Property Diversity across Artiodactyl Skulls.Integrative organismal biology (Oxford, England) · 2025Article
- Review
- Article
- Evaluation of gelatin bloom strength on gelatin methacryloyl hydrogel properties.Journal of the mechanical behavior of biomedical materials · 2024Article
- Equilibrium Tension and Compression Mechanical Properties of the Human Uterus.bioRxiv : the preprint server for biology · 2024Article
- An Assessment of the Mechanophysical and Hormonal Impact on Human Endometrial Epithelium Mechanics and Receptivity.International journal of molecular sciences · 2024Article
- Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels.npj women's health · 2024Article
- Breaking Physiological Barriers in Women's Health: Mucoadhesive and Stimuli-Responsive Nanomaterials.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
The uterus has critical biomechanical functions in pregnancy and undergoes dramatic material growth and remodeling from implantation to parturition. The intrinsic material properties of the human uterus and how they evolve in pregnancy are poorly understood. To address this knowledge gap and assess the heterogeneity of these tissues, the time-dependent material properties of all human uterine layers were measured with nanoindentation. The endometrium-decidua layer was found to be the least stiff, most viscous, and least permeable layer of the human uterus in nonpregnant and third-trimester pregnant tissues. In pregnancy, the endometrium-decidua becomes stiffer and less viscous with no material property changes observed in the myometrium or perimetrium. Additionally, uterine material properties did not significantly differ between third-trimester pregnant tissues with and without placenta accreta. The foundational data generated by this study will facilitate the development of physiologically accurate models of the human uterus to investigate gynecologic and obstetric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.