ArticleProceedings of the National Academy of Sciences of the United States of America2024
The structure of B-ARR reveals the molecular basis of transcriptional activation by cytokinin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 31 citations in OpenAlex.
- Leaf physiological and transcriptomic analyses provide insights into the regulatory network underlying high yield in yam under directional cultivation.BMC plant biology · 2026Article
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- Sugar signaling-mediated hormonal regulatory networks: molecular mechanisms underlying fruit abscission and development in seedless litchi.BMC plant biology · 2025Article
- Geminiviral replication enhancer hijacks a negative regulator of cytokinin signaling to facilitate viral infection.Plant communications · 2025Article
- Natural variation of CsUGT71A60 determines growth and cold tolerance via regulating cytokinin glycosylation in Camellia sinensis.Plant biotechnology journal · 2025Article
- Type-A and -C response regulator genes positively impact rice plant height and panicle architecture.Plant cell reports · 2025Article
- The Overexpression ofPlants (Basel, Switzerland) · 2025Article
- Non-Canonical Inter-Protein Interactions of Key Proteins Belonging to Cytokinin Signaling Pathways.Plants (Basel, Switzerland) · 2025Review
- Thidiazuron Enhances Strawberry Shoot Multiplication by Regulating Hormone Signal Transduction Pathways.International journal of molecular sciences · 2025Article
- Comprehensive analysis of morphology, transcriptomics, and metabolomics of banana (Frontiers in plant science · 2025Article
- Multi-omics analysis of organ-specific hormone distribution and molecular regulatory mechanisms inFrontiers in plant science · 2025Article
- ARR1 and AHP interactions in the multi-step phosphorelay system.Frontiers in plant science · 2025Article
- Genome-wide identification and expression analysis of two-component system genes in switchgrass (Panicum virgatum L.).BMC plant biology · 2024Article
- Advances in understanding the graft healing mechanism: a review of factors and regulatory pathways.Horticulture research · 2024Article
- Plant regeneration in the new era: from molecular mechanisms to biotechnology applications.Science China. Life sciences · 2024Review
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7 authors at 1 institution in 1 country.
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Abstract
The phytohormone cytokinin has various roles in plant development, including meristem maintenance, vascular differentiation, leaf senescence, and regeneration. Prior investigations have revealed that cytokinin acts via a phosphorelay similar to the two-component system by which bacteria sense and respond to external stimuli. The eventual targets of this phosphorelay are type-B ARABIDOPSIS RESPONSE REGULATORS (B-ARRs), containing the conserved N-terminal receiver domain (RD), middle DNA binding domain (DBD), and C-terminal transactivation domain. While it has been established for two decades that the phosphoryl transfer from a specific histidyl residue in ARABIDOPSIS HIS PHOSPHOTRANSFER PROTEINS (AHPs) to an aspartyl residue in the RD of B-ARRs results in a rapid transcriptional response to cytokinin, the underlying molecular basis remains unclear. In this work, we determine the crystal structures of the RD-DBD of ARR1 (ARR1
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