Evidence map›Paper›PMID 38198296›Full record

ArticleMemorias do Instituto Oswaldo Cruz2024

The absence of eosinophils is associated with early metastatic lesions in Leishmania amazonensis-infected mice.

Gregório Guilherme Almeida, Tassiane Assíria Martins Luehring, Pierre Henrique de Menezes Paixão, Rodrigo Pedro Soares, André Luís Branco de Barros, Rubens Lima do Monte-Neto, Wagner Luiz Tafuri, Deborah Aparecida Negrão-Corrêa, Ricardo Gonçalves

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gregório Guilherme AlmeidaUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Patologia Geral, Belo Horizonte, MG, Brasil.ORCID http://orcid.org/0000-0003-1108-1160
Tassiane Assíria Martins LuehringUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Patologia Geral, Belo Horizonte, MG, Brasil.
Pierre Henrique de Menezes PaixãoUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Patologia Geral, Belo Horizonte, MG, Brasil.
Rodrigo Pedro SoaresFundação Oswaldo Cruz-Fiocruz, Instituto René Rachou, Grupo de Biotecnologia Aplicada a Patógenos, Belo Horizonte, MG, Brasil.
André Luís Branco de BarrosUniversidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Belo Horizonte, MG, Brasil.
Rubens Lima do Monte-NetoFundação Oswaldo Cruz-Fiocruz, Instituto René Rachou, Grupo de Biotecnologia Aplicada a Patógenos, Belo Horizonte, MG, Brasil.
Wagner Luiz TafuriUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Patologia Geral, Belo Horizonte, MG, Brasil.
Deborah Aparecida Negrão-CorrêaUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Parasitologia, Belo Horizonte, MG, Brasil.
Ricardo GonçalvesUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Patologia Geral, Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais · BRFundação Oswaldo Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEosinophils are granulocytes that rapidly increase frequency in the bloodstream during helminthic infections and allergic responses. They are found in tissue infected by Leishmania during early disease, but their role during infection is not entirely understood.

objectivesWe aim to compare the disease due to Leishmania amazonensis in BALB/c and Δdbl-GATA1 mice, which lack eosinophils.

methodsBALB/c and Δdbl-GATA1 mice infected with L. amazonensis were observed for several weeks. The parasite load and dissemination pattern were assessed.

findingsThe Δdbl-GATA1 mice developed an anticipated dissemination of L. amazonensis and a worsening disease. No differences were found in the lesion development or the parasite load in the footpad among Δdbl-GATA1 mice and BALB/c eight weeks after infection. However, nine weeks after infection, massive growth of metastatic lesions appeared in several parts of the skin in Δdbl-GATA1 mice, weeks earlier than BALB/c. We observed increased parasites in the bloodstream, probably an essential dissemination route. Thirteen weeks after infection, metastatic lesions were found in all Δdbl-GATA1 mice. MAIN

conclusionThese results suggest a protective role of eosinophils in delaying the disease caused by L. amazonensis, although several limitations of this mice strain must be considered.

Indexed as

LeishmaniaLeishmania mexicanaAnimalsEosinophilsMiceParasite LoadSkin

Identifiers

PMID38198296
PMCPMC10777375
OpenAlexW4390658958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.