Evidence map›Paper›PMID 38198226›Full record

ArticleJournal of medicinal chemistry2024

Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.

Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A Andrei, Olivia Boyd, Naoko Masumoto, Ursula R Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. A cell-based Sonic Hedgehog signaling transduction system to identify additive and synergistic chemical interactions.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Markus RitzefeldDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.ORCID 0000-0002-9898-4110
Leran ZhangDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.
Zhangping XiaoDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.
Sebastian A AndreiDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.
Olivia BoydDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.ORCID 0000-0003-0789-6674
Naoko MasumotoDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.
Ursula R RodgersNational Heart and Lung Institute, Imperial College London, London SW7 2AZ, U.K.
Markus ArtelsmairDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.ORCID 0000-0002-2516-2925
Lea SeferDivision of Structural Biology, University of Oxford, Oxford OX3 7BN, U.K.
Angela HayesDivision of Cancer Therapeutics, Centre for Cancer Drug Discovery, Institute of Cancer Research, London SM2 5NG, U.K.
Efthymios-Spyridon GavriilDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.
Florence I RaynaudDivision of Cancer Therapeutics, Centre for Cancer Drug Discovery, Institute of Cancer Research, London SM2 5NG, U.K.ORCID 0000-0003-0957-6279
Rosemary BurkeDivision of Cancer Therapeutics, Centre for Cancer Drug Discovery, Institute of Cancer Research, London SM2 5NG, U.K.
Julian BlaggDivision of Cancer Therapeutics, Centre for Cancer Drug Discovery, Institute of Cancer Research, London SM2 5NG, U.K.
Henry S RzepaDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.ORCID 0000-0002-8635-8390
Christian SieboldDivision of Structural Biology, University of Oxford, Oxford OX3 7BN, U.K.
Anthony I MageeNational Heart and Lung Institute, Imperial College London, London SW7 2AZ, U.K.
Thomas Lanyon-HoggDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.
Edward W TateDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.ORCID 0000-0003-2213-5814
Imperial College London · GBInstitute of Cancer Research · GBLung Institute · USUniversity of Oxford · GB

Funding

Cancer Research UK 16402Cancer Research UK 26752Medical Research Council MC_PC_19040Wellcome Trust
6 · The paper itself

Abstract

Hedgehog signaling is involved in embryonic development and cancer growth. Functional activity of secreted Hedgehog signaling proteins is dependent on

Indexed as

Hedgehog ProteinsPyridinesHedgehog ProteinsPyridines

Identifiers

PMID38198226
PMCPMC10823475
OpenAlexW4390705898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.