Evidence map›Paper›PMID 38198100›Full record

ArticleBulletin of experimental biology and medicine2023

The Effect of Original Russian Neurotropic Drugs on Organic Anion Transporting Polypeptides OATP1B1 and OATP1B3.

P D Erokhina, Yu V Abalenikhina, P Yu Mylnikov, A V Petrov, S O Ganina, E A Konyakhin, A V Shchulkin, E N Yakusheva

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Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

P D ErokhinaRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
Yu V AbalenikhinaRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
P Yu MylnikovRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
A V PetrovRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
S O GaninaRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
E A KonyakhinRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
A V ShchulkinRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia. alekseyshulkin@rambler.ru.
E N YakushevaRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In experiments on HepG2 cells, we studied the effect of the original domestic neurotropic drugs omberacetam, fabomotizole, and ethylmethylhydroxypyridine succinate (EMHPS) (1-500 μM) on the activity and content of organic anion transporting polypeptides OATP1B1 and OATP1B3. It was shown that omberacetam (500 μM) increased the content of OATP1B1 and OATP1B3, fabomotizole did not affect the level of both transporters, and EMHPS (500 μM) increased the content of OATP1B1 compared to the control and did not affect the level of OATP1B3. The tested substances also reduced the OATP1B1/OATP1B3 ratio, as evidenced by a decrease in the penetration of atorvastatin, a substrate of the transporters, into HepG2 cells in the presence of omberacetam (100-500 μM), fabomotizole (500 μM), and EMHPS (10-500 μM). Evaluation of clinical significance of the obtained results, according to the FDA approach based on the calculation of the C

Indexed as

Organic Anion TransportersOrganic Anion Transporters, Sodium-IndependentBiological TransportLiver-Specific Organic Anion Transporter 1PeptidesRussiaSolute Carrier Organic Anion Transporter Family Member 1B3Liver-Specific Organic Anion Transporter 1Organic Anion TransportersOrganic Anion Transporters, Sodium-IndependentPeptidesSolute Carrier Organic Anion Transporter Family Member 1B3atorvastatinethylmethylhydroxypyridine succinatefabomotizoleOATP1B1/OATP1B3omberacetam

Identifiers

PMID38198100

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.