Evidence map›Paper›PMID 38198068›Full record

ArticleLasers in medical science2024

Association of Papacarie Duo® and low-level laser in antimicrobial photodynamic therapy (aPDT).

Roberta Janaina Soares Mendes, Nayanna Matos de Sousa, Guilherme Silva Furtado, Marco Aurélio Benini Paschoal, Andréa Dias Neves Lago

Abstract read
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Article in Lasers in medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Roberta Janaina Soares MendesDepartment of Dentistry I, Federal University of Maranhão (UFMA), Avenida Dos Portugueses, 1966, Vila Bacanga, São Luís, MA, 65080-805, Brazil. rjs.mendes@discente.ufma.br.ORCID http://orcid.org/0000-0002-6266-8810
Nayanna Matos de SousaDepartment of Dentistry I, Federal University of Maranhão (UFMA), Avenida Dos Portugueses, 1966, Vila Bacanga, São Luís, MA, 65080-805, Brazil.
Guilherme Silva FurtadoDepartment of Dentistry I, Federal University of Maranhão (UFMA), Avenida Dos Portugueses, 1966, Vila Bacanga, São Luís, MA, 65080-805, Brazil.
Marco Aurélio Benini PaschoalFederal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Andréa Dias Neves LagoFederal University of Maranhão (UFMA), São Luís, Brazil.

Funding

FAPEMA 04981/2018
6 · The paper itself

Abstract

Dental caries is a multifactorial, non-communicable disease. Effective treatment options for minimally invasive removal of carious tissue include Papacarie Duo® gel and antimicrobial photodynamic therapy (aPDT). aPDT involves a combination of a light source and photosensitizer. Given that Papacarie Duo® contains a percentage of blue dye, this study aims to explore the antimicrobial potential of Papacarie Duo® when associated with a light source against Streptococcus mutans strains. The chosen light source was a low-power diode laser (λ = 660 nm, E = 3 J, P = 100 mW, t = 30 s). To assess antimicrobial capacity, planktonic suspensions of Streptococcus mutans were plated on Brain Heart Infusion Agar (BHI) to observe the formation of inhibition halos. The studied groups included methylene blue (0.005%), Papacarie Duo®, distilled water (negative control), 2% chlorhexidine (positive control), Papacarie Duo® + laser, and methylene blue (0.005%) + laser. Following distribution onto plates, each group was incubated at 37 °C for 48 h under microaerophilic conditions. Inhibition halos were subsequently measured using a digital caliper. The results showed that chlorhexidine had the greatest antimicrobial effect followed by the group of irradiated methylene blue and irradiated Papacarie Duo®. All experimental groups demonstrated antimicrobial potential, excluding the negative control group. The study concludes that Papacarie Duo® exhibits antimicrobial properties when associated with a low-power diode laser.

Indexed as

Anti-Infective AgentsDental CariesPhotochemotherapyChlorhexidineHumansLasers, SemiconductorMethylene BluePapainAnti-Infective AgentsChlorhexidineMethylene BluePapacariePapainAnti-infective agentsDental cariesLow-level light therapyPhotochemotherapyProducts with antimicrobial action

Identifiers

PMID38198068

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.