Evidence map›Paper›PMID 38198002›Full record

ArticleAnnals of surgical oncology2024

Low-Dose Radiation Yields Lower Rates of Pathologic Response in Esophageal Cancer Patients.

Styliani Mantziari, Hugo Teixeira Farinha, Marguerite Messier, Michael Winiker, Pierre Allemann, Esat Mahmut Ozsahin, Nicolas Demartines, Guillaume Piessen, Markus Schäfer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Styliani MantziariDepartment of Visceral Surgery, Lausanne University Hospital CHUV, Lausanne, Switzerland. styliani.mantziari@chuv.ch.
Hugo Teixeira FarinhaDepartment of Visceral Surgery, Lausanne University Hospital CHUV, Lausanne, Switzerland.
Marguerite MessierDepartment of Digestive and Oncological Surgery, CHU Lille, Lille, France.
Michael WinikerDepartment of Visceral Surgery, Lausanne University Hospital CHUV, Lausanne, Switzerland.
Pierre AllemannDepartment of Visceral Surgery, Lausanne University Hospital CHUV, Lausanne, Switzerland.
Esat Mahmut OzsahinFaculty of Biology and Medicine, University of Lausanne UNIL, Lausanne, Switzerland.
Nicolas DemartinesDepartment of Visceral Surgery, Lausanne University Hospital CHUV, Lausanne, Switzerland.
Guillaume PiessenDepartment of Digestive and Oncological Surgery, CHU Lille, Lille, France.
Markus SchäferDepartment of Visceral Surgery, Lausanne University Hospital CHUV, Lausanne, Switzerland.
University of Lausanne · CHCentre Hospitalier Universitaire de Lille · FRUniversity Hospital of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough neoadjuvant chemoradiation (nCRT) followed by surgery is standard treatment for locally advanced esophageal or gastroesophageal junction (E/GEJ) cancer, the optimal radiation dose is still under debate.

objectiveThe aim of this study was to assess the impact of different preoperative radiation doses (41.4 Gy, 45 Gy or 50.4 Gy) on pathologic response and survival in E/GEJ cancer patients.

methodsAll consecutive patients with E/GEJ tumors, treated with curative intent between January 2009 and December 2016 in two referral centers were divided into three groups (41.4 Gy, 45 Gy and 50.4 Gy) according to the dose of preoperative radiotherapy. Pathologic complete response (pCR) rates, postoperative morbidity, overall survival (OS) and disease-free survival (DFS) were compared among the three groups, with separate analyses for adenocarcinoma (AC) and squamous cell carcinoma (SCC).

resultsFrom the 326 patients analyzed, 48 were included in the 41.4 Gy group (14.7%), 171 in the 45 Gy group (52.5%) and 107 in the 50.4 Gy group (32.8%). Postoperative complication rates were comparable (p = 0.399). A pCR was observed in 15%, 30%, and 34% of patients in the 41.4 Gy, 45 Gy and 50.4 Gy groups, respectively (p = 0.047). A 50.4 Gy dose was independently associated with pCR (odds ratio 2.78, 95% confidence interval 1.10-7.99) in multivariate analysis. Within AC patients, pCR was observed in 6.2% of patients in the 41.4 Gy group, 29.2% of patients in the 45 Gy group, and 22.7% of patients in the 50.4 Gy group (p = 0.035). No OS or DFS differences were observed.

conclusionsA pCR was less common after a preoperative radiation dose of 41.4 Gy in AC patients. Radiation dose had no impact on postoperative morbidity, long-term survival, and recurrence.

Indexed as

AdenocarcinomaCarcinoma, Squamous CellEsophageal NeoplasmsChemoradiotherapyEsophagectomyHumansNeoadjuvant TherapyRetrospective StudiesTreatment OutcomeEsophageal cancerNeoadjuvant treatmentPathologic responseRradiotherapySurvival

Identifiers

PMID38198002
PMCPMC10908612
OpenAlexW4390704316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.