Evidence map›Paper›PMID 38197990›Full record

ArticleEndocrine2024

Elevated atherogenic index of plasma associated with stroke risk in general Chinese.

Yijun Zhang, Shuohua Chen, Xue Tian, Qin Xu, Xue Xia, Xiaoli Zhang, Jing Li, Shouling Wu, Anxin Wang

Abstract read
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In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yijun Zhang *Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shuohua Chen *Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China.
Xue TianDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Qin XuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xue XiaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiaoli ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jing LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shouling WuDepartment of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China. drwusl@163.com.
Anxin WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. wanganxin@bjtth.org.ORCID 0000-0003-4351-2877
Capital Medical University · CNNorth China University of Science and Technology · CN

Funding

National Key Research and Development Program of China 2022YFC3600600
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe atherogenic index of plasma (AIP) is supposed to be associated with cardiovascular disease (CVD), but there is limited evidence on its longitudinal effect. Our study aimed to explore the associations between baseline and long-term AIP with the risk of stroke and its subtypes. METHODS AND

resultsA total of 97,959 participants free of stroke at baseline were included in the Kailuan study. The AIP was calculated as the logarithm of the ratio of triglyceride to high-density lipoprotein cholesterol. The updated mean AIP was calculated as the average of the AIP from baseline to the first occurrence of outcome or the end of follow-up. The outcome was the first occurrence of stroke, including ischemic stroke (IS) and intracerebral hemorrhage (ICH). We used univariable and multivariable Cox proportional hazard models to explore the association between AIP and the risk of stroke. During a median follow-up of 12.79 years, a total of 6307 participants developed stroke, including 5482 IS and 1024 ICH. Compared with the 1st quartile of baseline AIP, the multivariate-adjusted HR in the 4th quartile was 1.12 (95% CI, 1.03-1.22, p for trend <0.001) for stroke risk. Same results were found in IS, but no significant association was found for ICH. The associations between updated mean AIP and stroke and its subtypes showed similar results.

conclusionsElevated levels of both baseline and long-term updated mean AIP were associated with the risk of stroke and IS but not ICH in the general population.

Indexed as

AtherosclerosisStrokeTriglyceridesAdultAgedChinaCholesterol, HDLEast Asian PeopleFemaleFollow-Up StudiesHumansIschemic StrokeMaleMiddle AgedRisk FactorsCholesterol, HDLTriglyceridesAtherogenic index of plasmaLongitudinalRisk factorStroke

Identifiers

PMID38197990
OpenAlexW4390706326

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.