ArticleCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2024
Left ventricular hemodynamics with veno-arterial extracorporeal membrane oxygenation.
Article in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 15 citations in OpenAlex.
- Left ventricular loading during femoro-axillary veno-arterial ECMO: the role of ECMO-cardiac flow interaction and aortic arch anatomy.Critical care (London, England) · 2026Article
- Phenotyping hemodynamic response to veno-arterial extracorporeal membrane oxygenation in cardiogenic shock.Physiological reports · 2026Article
- Splanchnic ultrasound to guide unloading in VA-ECMO.The ultrasound journal · 2026Article
- Hemodynamic Effects of Adjunct Intra-Aortic Balloon Pumping During Veno-Arterial ECMO: A Pressure-Volume Loop Study.JACC. Case reports · 2026Article
- Recommendations in Extracorporeal Cardiopulmonary Resuscitation Post Resuscitation Care Via An International, Modified Delphi Approach.Journal of the American Heart Association · 2026Review
- [Post-Resuscitation care in the intensive care unit].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Review
- The effect of percutaneous coronary intervention after extracorporeal cardiopulmonary resuscitation on survival for out of hospital cardiac arrest: a causal inference analysis.Resuscitation plus · 2025Article
- Head-to-head comparison of V-A ECMO, Impella and ECPELLA in normal ovine hearts.Scientific reports · 2025Article
- Impact of Venoarterial Extracorporeal Membrane Oxygenation on Hemodynamics and Cardiac Mechanics: Insights From Pressure-Volume Loop Analysis.International journal of heart failure · 2025Review
- Increased VA-ECMO Pump Speed Reduces Left Atrial Pressure: Insights from a Novel Biventricular Heart Model.Bioengineering (Basel, Switzerland) · 2025Article
- Left ventricular energetics in patients receiving veno-arterial extracorporeal membrane oxygenation for extracorporeal cardiopulmonary resuscitation.Resuscitation · 2025Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere is considerable debate about the hemodynamic effects of veno-arterial extracorporeal membrane oxygenation (VA-ECMO).
aimsTo evaluate the changes in left ventricular (LV) function, volumes, and work in patients treated with VA-ECMO using invasive LV catheterization and three-dimensional echocardiographic volumes.
methodsPatients on VA-ECMO underwent invasive hemodynamic evaluation due to concerns regarding candidacy for decannulation. Hemodynamic parameters were reported as means±standard deviations or medians (interquartile ranges) after evaluating for normality. Paired comparisons were done to evaluate hemodynamics at the baseline (highest) and lowest tolerated levels of VA-ECMO support.
resultsTwenty patients aged 52.3 ± 15.8 years were included. All patients received VA-ECMO for refractory cardiogenic shock (5/20 SCAI stage D, 15/20 SCAI stage E). At 3.0 (2.0, 4.0) days after VA-ECMO cannulation, the baseline LV ejection fraction was 20% (15%, 27%). The baseline and lowest VA-ECMO flows were 4.0 ± 0.6 and 1.5 ± 0.6 L/min, respectively. Compared to the lowest flow, full VA-ECMO support reduced LV end-diastolic volume [109 ± 81 versus 134 ± 93 mL, p = 0.001], LV end-diastolic pressure (14 ± 9 vs. 19 ± 9 mmHg, p < 0.001), LV stroke work (1858 ± 1413 vs. 2550 ± 1486 mL*mmHg, p = 0.002), and LV pressure-volume area (PVA) (4507 ± 1910 vs. 5193 ± 2388, p = 0.03) respectively. Mean arterial pressure was stable at the highest and lowest flows (80 ± 16 vs. 75 ± 14, respectively; p = 0.08) but arterial elastance was higher at the highest VA-ECMO flow (4.9 ± 2.2 vs lowest flow 2.7 ± 1.6; p < 0.001).
conclusionsHigh flow VA-ECMO support significantly reduced LV end-diastolic pressure, end-diastolic volume, stroke work, and PVA compared to minimal support. The Ea was higher and MAP was stable or minimally elevated on high flow.
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