[Research progress of stationary phase of gas chromatography based on chiral organic frameworks].

Enantiomers typically show different pharmacological, toxicological, and physiological properties. Thus, the preparation of enantiopure compounds is of great significance for human health and sustainable development. Compared with asymmetric catalysis, enantiomeric separation is simpler, faster, and more efficient; as such, it has become the preferred method for obtaining pure enantiomers. At present, enantiomeric separation methods mainly include chromatography, nanochannel membrane separation, selective adsorption, and recrystallization. In particular, gas chromatography (GC) plays an important role in enantioseparation because of its high sensitivity, excellent reproducibility, and outstanding processing capacity for various enantiomers. The stationary phase is key to the separation efficiency of GC, and more efficient, stable, and cost-effective materials that could serve as stationary phases are constantly being explored. Organic frameworks, such as covalent organic frameworks (COFs), metal-organic frameworks (MOFs), porous organic cages (POCs), metal-organic cages (MOCs), and hydrogen-bonded organic frameworks (HOFs), possess large specific surface areas, high porosities, tunable pore sizes, and easy functionalization, rendering them promising candidates for the separation of mixed analytes. Research has shown that the use of organic frameworks as stationary phases for GC results in excellent column efficiency and high resolution for various analytes, including