Evidence map›Paper›PMID 38196654›Full record

ArticleResearch square2023

Development of a Kidney Microphysiological System Hardware Platform for Microgravity Studies.

Catherine Yeung, Kendan Jones-Isaac, Kevin Lindberg, Jade Yang, Jacelyn Bain, Micaela Ruiz, Greta Koenig, Paul Koenig, Stefanie Countryman, Jonathan Himmelfarb and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Catherine YeungUniversity of Washington.
Kendan Jones-IsaacUniversity of Washington.
Kevin LindbergUniversity of Washington.
Jade YangUniversity of Washington.
Jacelyn BainUniversity of Washington.
Micaela RuizUniversity of Washington.
Greta KoenigBioServe Space Technologies.
Paul KoenigBioServe Space Technologies.
Stefanie CountrymanBioServe Technologies.
Jonathan HimmelfarbKidney Research Institute.
Edward KellyUniv of Washington.ORCID 0000-0002-6534-9313

Funding

Using iPSCs to model patient outcomes in nephrotic syndromeUH3TR000504 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2014 to 2016
$6.1M
A Microphysiological System for Kidney Disease Modeling and Drug Efficacy TestingUG3TR002158 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2017 to 2018
$2.9M
Effects of microgravity on the structure and function of proximal and distal tubule MPSUH3TR002178 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN, KELLY, EDWARD J · 2019 to 2020
$842k
Effects of microgravity on the structure and function of proximal and distal tubule MPSUG3TR002178 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN, KELLY, EDWARD J · 2017 to 2018
$769k
NCATS NIH HHS UG3 TR002158NCATS NIH HHS UG3 TR002178NCATS NIH HHS UH3 TR000504NCATS NIH HHS UH3 TR002178
6 · The paper itself

Abstract

Study of the physiological effects of microgravity on humans is limited to non-invasive testing of astronauts. Microphysiological models of human organs recapitulate many functions and disease states. Here we describe the development of an advanced, semi-autonomous hardware platform to support kidney microphysiological model experiments in microgravity.

Indexed as

International Space StationKidneyMicrogravityMicrophysiologic SystemsTissue Chips in Space

Identifiers

PMID38196654
PMCPMC10775353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.