Evidence map›Paper›PMID 38196634›Full record

ArticleResearch square2023

Reprogramming Short-Chain Fatty Acid Metabolism Mitigates Tissue Damage for Streptococcus pyogenes Necrotizing Skin Infection.

Michael Caparon, Wei Xu, Tara Bradstreet, Zongsen Zou, Suzanne Hickerson, Yuan Zhou, Hongwu He, Brian Edelson

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Michael CaparonWashington University School of Medicine.
Wei XuWashington University School of Medicine.
Tara BradstreetWashington University School of Medicine.
Zongsen ZouWashington University School of Medicine.
Suzanne HickersonWashington University School of Medicine.
Yuan ZhouJiangxi Normal University.
Hongwu HeCentral China Normal University.
Brian EdelsonWashington University School of Medicine.
Washington University in St. Louis · USCentral China Normal University · CN

Funding

Regulation of Immune Responses to Mycobacterium tuberculosis InfectionR01AI132653 · NIAID · WASHINGTON UNIVERSITY · PI EDELSON, BRIAN TODD, STALLINGS, CHRISTINA LEIGH · 2018 to 2022
$3.0M
Novel Therapeutic Approach to Invasive Group A Streptococcal DiseaseR21AI163825 · NIAID · WASHINGTON UNIVERSITY · PI CAPARON, MICHAEL G. · 2022 to 2023
$432k
Short Chain Fatty Acids and Streptococcus Pyogenes VirulenceR56AI070759 · NIAID · WASHINGTON UNIVERSITY · PI CAPARON, MICHAEL G. · 2019 to 2019
$353k
NIAID NIH HHS R01 AI132653NIAID NIH HHS R21 AI163825NIAID NIH HHS R56 AI070759
6 · The paper itself

Abstract

Disease Tolerance (DT) is a host response to infection that limits collateral damage to host tissues while having a neutral effect on pathogen fitness. Previously, we found that the pathogenic lactic acid bacterium

Indexed as

fermentationHDACIL-10macrophageneutrophilsshort-chain fatty-acidskin-infectionStreptococcustherapeutic

Identifiers

PMID38196634
PMCPMC10775361
OpenAlexW4390145520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.