Evidence map›Paper›PMID 38196633›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Genome-wide QTL mapping across three tissues highlights several Alzheimer's and Parkinson's disease loci potentially acting via DNA methylation.

Olena Ohlei, Yasmine Sommerer, Valerija Dobricic, Jan Homann, Laura Deecke, Marcel Schilling, David Bartrés-Faz, Gabriele Cattaneo, Sandra Düzel, Anders M Fjell and 13 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 5 countries.

Olena OhleiLübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.
Yasmine SommererLübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.
Valerija DobricicLübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.
Jan HomannInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Laura DeeckeInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Marcel SchillingLübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.
David Bartrés-FazDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
Gabriele CattaneoInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Barcelona, Spain.
Sandra DüzelCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Anders M FjellCenter for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway.
Ulman LindenbergerCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Álvaro Pascual-LeoneHinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, MA, USA.
Sanaz Sedghpour SabetInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Cristina Solé-PadullésDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
Josep M TormosInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Barcelona, Spain.
Valentin M VetterBiology of Aging Working Group, Department of Endocrinology and Metabolic Diseases, Division of Lipid Metabolism, Charité-Universitätsmedizin Berlin (corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin), Berlin, Germany.
Kristine B WalhovdCenter for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway.
Tanja WesseInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Michael WittigInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Ilja DemuthBiology of Aging Working Group, Department of Endocrinology and Metabolic Diseases, Division of Lipid Metabolism, Charité-Universitätsmedizin Berlin (corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin), Berlin, Germany.
Christina M LillInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Lars BertramLübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.
Harvard University · USUniversity of Lübeck · DEInstitut d'Investigació Biomédica de Bellvitge · ESOslo University Hospital · NOUniversity of Münster · DEHumboldt-Universität zu Berlin · DEMax Planck Institute for Human Development · DEUniversitat Autònoma de Barcelona · ES

Funding

The Role of Inflammation in the Pathophysiology of Delirium and its Associated Long-Term Cognitive DeclineP01AG031720 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2010 to 2022
$26.7M
Personalized brain activity modulation to improve balance and cognition in elderly fallersR01AG059089 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI MANOR, BRADLEY D. · 2018 to 2022
$3.2M
Multifocal transcranial current stimulation for cognitive and motor dysfunction in dementiaR01AG076708 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI MANOR, BRADLEY D., PASCUAL-LEONE, ALVARO · 2022 to 2024
$2.3M
System biology approach to decode molecular mechanism of glucose metabolism in AD and dementiaR03AG072233 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI JEONG, SOHYUN · 2022 to 2023
$320k
NIA NIH HHS P01 AG031720NIA NIH HHS R01 AG059089NIA NIH HHS R01 AG076708NIA NIH HHS R03 AG072233
6 · The paper itself

Abstract

DNA methylation (DNAm) is an epigenetic mark with essential roles in disease development and predisposition. Here, we created genome-wide maps of methylation quantitative trait loci (meQTL) in three peripheral tissues and used Mendelian randomization (MR) analyses to assess the potential causal relationships between DNAm and risk for two common neurodegenerative disorders, i.e. Alzheimer's disease (AD) and Parkinson's disease (PD). Genome-wide single nucleotide polymorphism (SNP; ~5.5M sites) and DNAm (~850K CpG sites) data were generated from whole blood (n=1,058), buccal (n=1,527) and saliva (n=837) specimens. We identified between 11 and 15 million genome-wide significant (p<10

Indexed as

Alzheimer’s disease (AD)colocalizationGenome-wide association study (GWAS)Mendelian randomization (MR)methylation quantitative trait locus (meQTL) analysisParkinson’s disease (PD)

Identifiers

PMID38196633
PMCPMC10775408
OpenAlexW4390168419

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.