Evidence map›Paper›PMID 38196611›Full record

ArticlebioRxiv : the preprint server for biology2023

Lysine-36 of

John C Brown, Benjamin D McMichael, Vasudha Vandadi, Aadit Mukherjee, Harmony R Salzler, A Gregory Matera

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

John C BrownIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.
Benjamin D McMichaelIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.
Vasudha VandadiIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.
Aadit MukherjeeDepartment of Biology, University of North Carolina, Chapel Hill, NC, USA.
Harmony R SalzlerIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.
A Gregory MateraIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-6406-0630
University of North Carolina at Chapel Hill · US

Funding

Role of histone PTMs in epigenetic control of metazoan transcription and RNA processingR35GM136435 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI A. Gregory Matera · 2020 to 2026
$4.7M
NIGMS NIH HHS R35 GM136435
6 · The paper itself

Abstract

Aging is a multifactorial process that disturbs homeostasis, increases disease susceptibility, and ultimately results in death. Although the definitive set of molecular mechanisms responsible for aging remain to be discovered, epigenetic change over time is proving to be a promising piece of the puzzle. Several posttranslational histone modifications (PTMs) have been linked to the maintenance of longevity. Here, we focus on lysine-36 of the replication-independent histone protein, H3.3 (H3.3K36). To interrogate the role of this residue in

Identifiers

PMID38196611
PMCPMC10775331
OpenAlexW4387165121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.