Evidence map›Paper›PMID 38196610›Full record

ArticleResearch square2023

Genetic and Survey Data Improves Performance of Machine Learning Model for Long COVID.

Wei-Qi Wei, Christopher Guardo, Srushti Gandireddy, Chao Yan, Henry Ong, Vern Kerchberger, Alyson Dickson, Emily Pfaff, Hiral Master, Melissa Basford and 11 more

Abstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Wei-Qi WeiVanderbilt University Medical Center.ORCID 0000-0003-4985-056X
Christopher GuardoVanderbilt University Medical Center.
Srushti GandireddyVanderbilt University Medical Center.
Chao YanVanderbilt University Medical Center.ORCID 0000-0002-6719-1388
Henry OngVanderbilt University Medical Center.
Vern KerchbergerVanderbilt University Medical Center.
Alyson DicksonVanderbilt University Medical Center.ORCID 0000-0003-3404-3802
Emily PfaffUniversity of North Carolina, USA.ORCID 0000-0002-6840-9756
Hiral MasterVanderbilt University Medical Center.
Melissa BasfordVanderbilt Institute of Clinical and Translational Research/Vanderbilt University Medical Center.
Nguyen TranStanford University School of Medicine.
Salvatore MancusoStanford University School of Medicine.
Toufeeq SyedUTHealth Houston.
Zhongming ZhaoUniversity of Texas HSC Houston.ORCID 0000-0002-3477-0914
QiPing FengDepartment of Medicine, Vanderbilt University Medical Center.
Melissa HaendelUniversity of Colorado.ORCID 0000-0001-9114-8737
Christopher LuntAll of Us Research Program.
Geoffrey GinsburgAll of Us Research Program, National Institutes of Health.ORCID 0000-0003-4739-9808
Christopher ChuteJohns Hopkins University.ORCID 0000-0001-5437-2545
Joshua DennyAll of Us Research Program, National Institutes of Health.
Dan RodenDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN.

Funding

Vanderbilt Genome-Electronic Records (VGER) ProjectU01HG011181 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAN M RODEN, Digna R Velez Edwards · 2020 to 2026
$7.0M
Drug repositioning for Alzheimer's disease via genetics, electronic health records, and human iPSC modelsR01AG069900 · NIA · VANDERBILT UNIVERSITY · PI LI, BINGSHAN, WEI, WEI-QI · 2021 to 2025
$4.0M
PheMAP: Measured, Automated Profile to Facilitate High Throughput PhenotypingR01GM139891 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WEI, WEI-QI · 2021 to 2024
$1.7M
NHGRI NIH HHS U01 HG011181NIA NIH HHS R01 AG069900NIGMS NIH HHS R01 GM139891
6 · The paper itself

Abstract

Over 200 million SARS-CoV-2 patients have or will develop persistent symptoms (long COVID). Given this pressing research priority, the National COVID Cohort Collaborative (N3C) developed a machine learning model using only electronic health record data to identify potential patients with long COVID. We hypothesized that additional data from health surveys, mobile devices, and genotypes could improve prediction ability. In a cohort of SARS-CoV-2 infected individuals (n=17,755) in the All of Us program, we applied and expanded upon the N3C long COVID prediction model, testing machine learning infrastructures, assessing model performance, and identifying factors that contributed most to the prediction models. For the survey/mobile device information and genetic data, extreme gradient boosting and a convolutional neural network delivered the best performance for predicting long COVID, respectively. Combined survey, genetic, and mobile data increased specificity and the Area Under Curve the Receiver Operating Characteristic score versus the original N3C model.

Identifiers

PMID38196610
PMCPMC10775401

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.