Evidence map›Paper›PMID 38196595›Full record

ArticleResearch square2023

Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane.

Erica Saphire, Zhe Li Salie, Zunlong Ke, Peter Halfmann, Lisa Evans DeWald, Sara McArdle, Ariadna Grinyo, Edgar Davidson, Sharon Schendel, Chitra Hariharan and 16 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 10 institutions in 4 countries.

Erica SaphireLa Jolla Institute for Immunology.ORCID 0000-0002-1206-7451
Zhe Li SalieEli Lilly.
Zunlong KeMedical Research Council.
Peter HalfmannUniversity of Wisconsin - Madison.ORCID 0000-0002-1648-1625
Lisa Evans DeWaldEmergent Biosolutions.
Sara McArdleLa Jolla Institute for Immunology.ORCID 0000-0003-3795-3772
Ariadna GrinyoIntegral Molecular.
Edgar DavidsonIntegral Molecular.
Sharon SchendelLa Jolla Institute for Immunology.ORCID 0000-0002-5062-7261
Chitra HariharanLa Jolla Institute for Immunology.
Michael NorrisUniveristy of Toronto Canada.
Xiaoying YuLa Jolla Institute for Immunology.
Chakravarthy ChennareddyEmory University.
Xiaoli XiongGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences.ORCID 0000-0002-4632-9122
Megan HeinrichPage 2/29 Zalgen Labs, LLC.
Michael HolbrookNational Institute of Allergy and Infectious Diseases (NIAID) Integrated Research Facility, National Institutes of Health (NIH).ORCID 0000-0002-0824-2667
Benjamin DoranzIntegral Molecular.ORCID 0000-0002-8245-3083
Kathryn HastieLa Jolla Institute for Immunology.
Yoshihiro KawaokaUniversity of Wisconsin-Madison.ORCID 0000-0001-5061-8296
Luis BrancoZalgen.
Jens KuhnNational Institutes of Health (NIH).ORCID 0000-0002-7800-6045
John BriggsMedical Research Council.
Gabriella WorwaNational Institutes of Health.
Carl DavisEmory University.
Rafi AhmedEmory University School of Medicine.ORCID 0000-0002-9591-2621
La Jolla Institute for Immunology · USEmory University · USNational Institutes of Health · USIntegral Molecular (United States) · USMedical Research Council · GBUniversity of Wisconsin–Madison · USEli Lilly (Singapore) · SGGuangzhou Institutes of Biomedicine and Health · CNKALGEn Consultants (United States) · USNational Institute of Allergy and Infectious Diseases · US

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Specific and Broadly Active Monoclonal Antibody Therapeutics Against The FilovirusesU19AI142790 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI GARRY, ROBERT F · 2019 to 2023
$40.0M
X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
NCI NIH HHS 75N91019D00024NCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003INIAID NIH HHS HHSN272200700016INIAID NIH HHS HHSN272201400058CNIAID NIH HHS HHSN272201800013CNIAID NIH HHS U19 AI142790NIGMS NIH HHS P41 GM103393NIH HHS S10 OD012289
6 · The paper itself

Abstract

Monoclonal antibodies (mAbs) against Ebola virus (EBOV) glycoprotein (GP

Indexed as

3A6Animal studyantibodyEbola virusEBOVefficacy studymAbmembrane proximal external regionmonoclonal antibodyMPERstalk

Identifiers

PMID38196595
PMCPMC10775387
OpenAlexW4390114269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.