Evidence map›Paper›PMID 38196593›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Kapil K Upadhyay, Xiaomeng Du, Yanhua Chen, Elizabeth K Speliotes, Graham F Brady

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    2025
5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kapil K UpadhyayDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0000-5085
Xiaomeng DuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Yanhua ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Elizabeth K SpeliotesDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Graham F BradyDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-8376-5871
University of Michigan · US

Funding

Human population based genetic studies to elucidate the biology of NAFLDR01DK107904 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2016 to 2020
$3.4M
Identification and functional impact of NAFLD associated genetic variantsR01DK106621 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2015 to 2019
$3.3M
Integrative Polygenic Genetic Studies of Non-alcoholic Fatty Liver DiseaseR01DK131787 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2022 to 2025
$2.7M
Identification and Characterization of Loci Associated with Non-alcoholic Fatty Liver DiseaseR01DK128871 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALLRED, NICHOLETTE D., SPELIOTES, ELIZABETH K · 2021 to 2024
$2.6M
Nuclear lamins and the hepatocyte nuclear envelope in nonalcoholic fatty liver diseaseK08DK120948 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRADY, GRAHAM F. · 2020 to 2024
$839k
NIDDK NIH HHS K08 DK120948NIDDK NIH HHS R01 DK106621NIDDK NIH HHS R01 DK107904NIDDK NIH HHS R01 DK128871NIDDK NIH HHS R01 DK131787
6 · The paper itself

Abstract

The R644C variant of lamin A is controversial, as it has been linked to multiple phenotypes in familial studies, but has also been identified in apparently healthy volunteers. Here we present data from a large midwestern US cohort showing that this variant associates genetically with hepatic steatosis, and with related traits in additional publicly available datasets, while

Indexed as

geneticslaminopathymetabolic diseasenuclear laminasteatosis

Identifiers

PMID38196593
PMCPMC10775342
OpenAlexW4390106045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.