Evidence map›Paper›PMID 38196587›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Multi-site validation of a functional assay to adjudicate

Joanne G Ma, Matthew J O'Neill, Ebony Richardson, Kate L Thomson, Jodie Ingles, Ayesha Muhammad, Joseph F Solus, Giovanni Davogustto, Katherine C Anderson, M Benjamin Shoemaker and 10 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 3 countries.

Joanne G MaMark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Matthew J O'NeillVanderbilt University School of Medicine, Nashville, TN, USA.
Ebony RichardsonClinical Genomics Laboratory, Centre for Population Genomics, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia and Murdoch Children Research Institute, Melbourne, Australia.
Kate L ThomsonOxford Genetics Laboratories, Churchill Hospital, Oxford, UK.
Jodie InglesClinical Genomics Laboratory, Centre for Population Genomics, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia and Murdoch Children Research Institute, Melbourne, Australia.
Ayesha MuhammadVanderbilt University School of Medicine, Nashville, TN, USA.
Joseph F SolusVanderbilt Center for Arrhythmia Research and Therapeutics (VanCART), Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Giovanni DavogusttoDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Katherine C AndersonDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
M Benjamin ShoemakerDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Andrew B StergachisUniversity of Washington School of Medicine, Department of Medicine, Seattle, WA, USA.
Brendan J FloydStanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3185-0174
Kyla DunnStanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA, USA.
Victoria N ParikhStanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA, USA.
Henry ChubbStanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA, USA.
Mark J PerrinDepartment of Genomic Medicine, Royal Melbourne Hospital, Victoria, Australia.
Dan M RodenVanderbilt Center for Arrhythmia Research and Therapeutics (VanCART), Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-6302-0389
Jamie I VandenbergMark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.ORCID 0000-0002-3859-3716
Chai-Ann NgMark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.ORCID 0000-0002-3120-5450
Andrew M GlazerVanderbilt Center for Arrhythmia Research and Therapeutics (VanCART), Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University Medical Center · USVictor Chang Cardiac Research Institute · AUStanford Medicine · USVanderbilt University · USGarvan Institute of Medical Research · AUChurchill Hospital · GBThe Royal Melbourne Hospital · AUUniversity of Washington · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Systematically mapping variant effects for cardiovascular genesR01HL164675 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ASHLEY, EUAN A, RODEN, DAN M · 2022 to 2025
$8.1M
Advancing the implementation of variant-level functional data into clinical databases and clinical practiceR01HG013025 · NHGRI · UNIVERSITY OF WASHINGTON · PI Lea Starita, Andrew Ben Stergachis · 2023 to 2026
$3.1M
Functional Genomics of Cardiac Sodium Channel VariantsR01HL149826 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2020 to 2023
$2.9M
High-throughput discovery of disease-associated ion channel variantsR35GM150465 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Andrew M. Glazer · 2023 to 2026
$1.8M
A pipeline for identifying disease-causing variants in transmembrane proteinsR00HG010904 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, ANDREW M. · 2022 to 2024
$737k
Nanion SynchroPatch 384 for Automated, High-throughput ElectrophysiologyS10OD025281 · OD · VANDERBILT UNIVERSITY · PI WEAVER, C DAVID · 2018 to 2018
$571k
Aberrant Splicing in the Cardiac ArrhythmiasF30HL163923 · NHLBI · VANDERBILT UNIVERSITY · PI O'NEILL, MATTHEW · 2022 to 2023
$61k
NCI NIH HHS P30 CA068485NHGRI NIH HHS R00 HG010904NHGRI NIH HHS R01 HG013025NHLBI NIH HHS F30 HL163923NHLBI NIH HHS R01 HL149826NHLBI NIH HHS R01 HL164675NIDDK NIH HHS P30 DK058404NIGMS NIH HHS R35 GM150465NIGMS NIH HHS T32 GM007347NIH HHS S10 OD025281
6 · The paper itself

Abstract

Brugada Syndrome (BrS) is an inheritable arrhythmia condition that is associated with rare, loss-of-function variants in the cardiac sodium channel gene,

Identifiers

PMID38196587
PMCPMC10775332
OpenAlexW4389989924

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.