Evidence map›Paper›PMID 38196581›Full record

ArticlemedRxiv : the preprint server for health sciences2024

A maternal germline mutator phenotype in a family affected by heritable colorectal cancer.

Candice L Young, Annabel C Beichman, David Mas-Ponte, Shelby L Hemker, Luke Zhu, Jacob O Kitzman, Brian H Shirts, Kelley Harris

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Candice L YoungDepartment of Genome Sciences, University of Washington, 3720 15th Ave NE, Seattle, WA 98195.ORCID 0000-0001-6112-4064
Annabel C BeichmanDepartment of Genome Sciences, University of Washington, 3720 15th Ave NE, Seattle, WA 98195.ORCID 0000-0002-6991-587X
David Mas-PonteDepartment of Genome Sciences, University of Washington, 3720 15th Ave NE, Seattle, WA 98195.ORCID 0000-0001-7409-305X
Shelby L HemkerDepartment of Human Genetics, University of Michigan, 1241 Catherine St, Ann Arbor, MI 48109.ORCID 0000-0002-9135-7042
Luke ZhuDepartment of Genome Sciences, University of Washington, 3720 15th Ave NE, Seattle, WA 98195.ORCID 0000-0002-6324-1464
Jacob O KitzmanDepartment of Human Genetics, University of Michigan, 1241 Catherine St, Ann Arbor, MI 48109.ORCID 0000-0002-6145-882X
Brian H ShirtsDepartment of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific St, Seattle, WA 98195.ORCID 0000-0002-7188-6764
Kelley HarrisDepartment of Genome Sciences, University of Washington, 3720 15th Ave NE, Seattle, WA 98195.ORCID 0000-0003-0302-2523
University of Washington · USSt. Catherine University · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZASeattle Pacific University · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Biological Mechanisms of Healthy Aging Training GrantT32AG066574 · NIA · UNIVERSITY OF WASHINGTON · PI David J. Marcinek, Jessica E Young · 2020 to 2026
$5.3M
Investigating the landscape and genetic architecture of germline mutagenesisR35GM133428 · NIGMS · UNIVERSITY OF WASHINGTON · PI Kelley Harris · 2019 to 2026
$2.8M
Massively parallel experimental measurement of variant functional impactsR01GM129123 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KITZMAN, JACOB OTTO · 2018 to 2022
$2.1M
Expanding the Reach of Massively Parallel Variant Effect ScreensR35GM153286 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jacob Otto Kitzman · 2024 to 2026
$1.5M
NIA NIH HHS T32 AG066574NIGMS NIH HHS R01 GM129123NIGMS NIH HHS R35 GM133428NIGMS NIH HHS R35 GM153286NIGMS NIH HHS T32 GM007270
6 · The paper itself

Abstract

Variation in DNA repair genes can increase cancer risk by elevating the rate of oncogenic mutation. Defects in one such gene,

Indexed as

de novo mutation callinggermline mutagenesismutational signaturemutator alleleMUTYH-associated polyposisoxidative damagepedigree

Identifiers

PMID38196581
PMCPMC10775336
OpenAlexW4389954778

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.