ArticleResearch square2023
Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma.
Shruti V Patil, Balasankara Reddy Kaipa, Sujata Ranshing, Yogapriya Sundaresan, J Cameron Millar, Bhavani Nagarajan, Charles Kiehlbauch, Qihong Zhang, Ankur Jain, Charles C Searby and 4 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors at 3 institutions in 1 country.
Shruti V PatilUniversity of North Texas Health Science Center at Fort Worth.
Balasankara Reddy KaipaUniversity of California.
Sujata RanshingUniversity of North Texas Health Science Center at Fort Worth.
Yogapriya SundaresanUniversity of California.
J Cameron MillarUniversity of North Texas Health Science Center at Fort Worth.
Bhavani NagarajanUniversity of North Texas Health Science Center at Fort Worth.
Charles KiehlbauchUniversity of North Texas Health Science Center at Fort Worth.
Qihong ZhangUniversity of Iowa.
Ankur JainUniversity of Iowa.
Charles C SearbyUniversity of Iowa.
Todd E ScheetzUniversity of Iowa.
Abbot F ClarkUniversity of North Texas Health Science Center at Fort Worth.
Val C SheffieldUniversity of Iowa.
Gulab S ZodeUniversity of California.
University of North Texas · USUniversity of Iowa · USUniversity of California System · US
Funding
Stem Cell and Organoid CoreP30EY025580 · NEI · UNIVERSITY OF IOWA · PI Michael G Anderson · 2016 to 2026
$6.9MCrosstalk Between Unfolded Protein Response and Autophagy for the Treatment of GlaucomaR01EY026177 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2016 to 2025
$3.8MNEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vladimir Jivkov Kefalov · 2022 to 2026
$3.7MGlucocorticoids, ocular hypertension and glaucomaR01EY030967 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI CLARK, ABBOT FREDERICK, GEISERT, ELDON E · 2020 to 2024
$2.8MNovel Genome Editing for the Treatment of GlaucomaR01EY030366 · NEI · UNIVERSITY OF IOWA · PI CLARK, ABBOT FREDERICK, SHEFFIELD, VAL C. · 2019 to 2023
$2.7MTargeting ER Stress Pathway Using Sodium 4-Phenylbutyrate for the Treatment of POAGR01EY028616 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2018 to 2021
$1.4MNEI NIH HHS P30 EY025580NEI NIH HHS P30 EY034070NEI NIH HHS R01 EY026177NEI NIH HHS R01 EY028616NEI NIH HHS R01 EY030366NEI NIH HHS R01 EY030967
6 · The paper itselfAbstract
Indexed as
ER stressGene therapyGenome editing for glaucomaIntraocular pressureLentiviral particlesMyocilin-associated GlaucomaTrabecular meshworkViral vectors
Identifiers
PMID38196579
PMCPMC10775399
OpenAlexW4389943703
What OpenQuestion holds
Textmetadata
LicenceCC BY
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