Trial reportThe American journal of psychiatry2024
Mindfulness-Oriented Recovery Enhancement for Veterans and Military Personnel on Long-Term Opioid Therapy for Chronic Pain: A Randomized Clinical Trial.
Trial report in The American journal of psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Effectiveness of savoring interventions: A systematic review and meta-analysis of randomized controlled trials.Applied psychology. Health and well-being · 2026Pooled it
- Pooled it
- A randomized controlled trial of online mindfulness-based stress reduction in chronic stroke.Rehabilitation psychology · 2026Trial
- Mindfulness in the Orthopedic Clinic Waiting Room Decreases Pain: Results From A Randomized Controlled Trial.International journal of behavioral medicine · 2026Trial
- Implicit opioid associations in OUD treatment: prediction of treatment response and moderation by mindfulness-oriented recovery enhancement.Psychological medicine · 2026Trial
- Enhancing interoceptive awareness in chronic pain and opioid misuse via mindfulness-oriented recovery enhancement.Drug and alcohol dependence · 2025Trial
- Positive Emotion Dysregulation in Opioid Use Disorder and Normalization by Mindfulness-Oriented Recovery Enhancement: A Secondary Analysis of a Randomized Clinical Trial.JAMA psychiatry · 2025Trial
- Mindfulness vs Cognitive Behavioral Therapy for Chronic Low Back Pain Treated With Opioids: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Mindfulness-Oriented Recovery Enhancement Reduces Illicit Substance Craving Among People with Alcohol Use Disorder and Polysubstance Use.Substance use & misuse · 2025Trial
- Brain mechanisms supporting mindfulness-based chronic pain relief: A randomized, sham-mindfulness meditation controlled mechanistic clinical trial protocol.Contemporary clinical trials communications · 2026Article
- Evaluation of a Spanish-language Adaptation of Brief Mindfulness-Oriented Recovery Enhancement for Chronic Pain: A Pilot Randomized Controlled Trial.International journal of behavioral medicine · 2026Article
- Nondual Awareness as a Novel Chronic Pain Relieving Mechanism.Psychology of consciousness (Washington, D.C.) · 2026Article
- Diminished anticipatory pleasure predicts anhedonia in women with endometrisois: a case-control study.BMC women's health · 2026Article
- Positive Emotion Regulation in Addiction: A New Frontier for Recovery Science.Current addiction reports · 2026Review
- Anhedonia: Current and future treatments.PCN reports : psychiatry and clinical neurosciences · 2025Review
- Association Between Educational Attainment and Chronic Pain: A Mediation Mendelian Randomization Study.Journal of pain research · 2025Article
- How Bud Craig's Insights Reshape the Research on Pain and Mind-Body Therapies.Current topics in behavioral neurosciences · 2025Review
- Commentary With Study Protocol: Implementation and Effectiveness of Mindfulness-Oriented Recovery Enhancement (MORE) as an Adjunct to Methadone Treatment for Opioid Use Disorder (IMPOWR-MORE).Substance use & addiction journal · 2025Article
- Chronic post-surgical pain after total knee arthroplasty: a narrative review.Perioperative medicine (London, England) · 2024Article
- Immediate Effects of Mindful Awareness in Body-Oriented Therapy as an Adjunct to Medication for Opioid Use Disorder.Mindfulness · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis randomized clinical trial evaluated the efficacy of Mindfulness-Oriented Recovery Enhancement (MORE) among past and present U.S. military personnel with prescriptions for long-term opioid therapy for chronic pain.
methodsIn this clinical trial, 230 past and present military personnel with prescriptions for long-term opioid therapy were randomized in a 1:1 ratio to MORE or supportive psychotherapy (initially delivered in person and then via videoconferencing after the onset of the COVID-19 pandemic). Primary outcomes were chronic pain, measured by the Brief Pain Inventory, and aberrant drug-related behaviors, measured by the Current Opioid Misuse Measure, through 8 months of follow-up. Opioid dose was a key secondary outcome. Other outcomes included psychiatric symptoms, catastrophizing, positive affect, ecological momentary assessments of opioid craving, and opioid attentional bias.
resultsMORE was superior to supportive psychotherapy through the 8-month follow-up in reducing pain-related functional interference, pain severity, and opioid dose. MORE reduced daily opioid dose by 20.7%, compared with a dose reduction of 3.9% with supportive psychotherapy. Although there was no overall between-group difference in opioid misuse, the in-person MORE intervention outperformed supportive psychotherapy for reducing opioid misuse. MORE reduced anhedonia, pain catastrophizing, craving, and opioid attentional bias and increased positive affect to a greater extent than supportive psychotherapy. MORE also modulated therapeutic processes, including mindful reinterpretation of pain sensations, nonreactivity, savoring, positive attention, and reappraisal.
conclusionsAmong past and present U.S. military personnel, MORE led to sustained decreases in chronic pain, opioid use, craving, and opioid cue reactivity. MORE facilitated opioid dose reduction while preserving adequate pain control and preventing mood disturbances, suggesting its utility for safe opioid tapering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.