SynthesisMolecular psychiatry2024
Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup.
Synthesis in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Biological treatments for co-occurring eating disorders and psychological trauma: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury.JAMA network open · 2023Pooled it
- Network-level structural alterations distinguish persistent from remitted post-traumatic stress disorder: a morphometric covariance approach.European journal of psychotraumatology · 2026Article
- Exploring the shared genetic architecture between post-traumatic stress disorder (PTSD) and obstructive sleep apnea (OSA).European journal of psychotraumatology · 2026Article
- Harnessing the power of FAIR data to advance sex/gender insights in psychotraumatology.European journal of psychotraumatology · 2026Review
- Structural covariance, regional topology, and volumetric aspects of amygdala subnuclei in posttraumatic stress disorder using ultra-high field imaging.Molecular psychiatry · 2026Article
- Long-term neurostructural and psychological effects of war stress in two generations of civilians from the former Yugoslavia.Scientific reports · 2026Article
- Disrupted intrathalamic and thalamocortical structural covariance networks in posttraumatic stress disorder.Network neuroscience (Cambridge, Mass.) · 2026Article
- Functional connectivity profiles of amygdala subregions in posttraumatic stress disorder.Translational psychiatry · 2025Article
- Data-Driven Approach to Dynamic Resting State Functional Connectivity in Post-Traumatic Stress Disorder: An ENIGMA-PGC PTSD Study.Human brain mapping · 2025Article
- Advances in Cerebellar TMS Therapy: An Updated Systematic Review on Multi-Session Interventions.Biomedicines · 2025Review
- Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury.Biology · 2025Review
- Cerebellar microstructural abnormalities in patients with somatic symptom disorders.BMC psychiatry · 2025Article
- Neuroscience-based relational art therapy and deep brain reorienting in the treatment of dissociative identity disorder.Frontiers in psychology · 2025Article
Corrections and comments
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Authors and funding
110 authors at 20 institutions in 12 countries.
Funding
Abstract
Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.