Evidence map›Paper›PMID 38195980›Full record

SynthesisMolecular psychiatry2024

Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup.

Ashley A Huggins, C Lexi Baird, Melvin Briggs, Sarah Laskowitz, Ahmed Hussain, Samar Fouda, Courtney Haswell, Delin Sun, Lauren E Salminen, Neda Jahanshad and 100 more

Open access · hybridAbstract readMeta-Analysis
In one paragraph

Synthesis in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study.European psychiatry : the journal of the Association of European Psychiatrists · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

110 authors at 20 institutions in 12 countries.

Ashley A HugginsBrain Imaging and Analysis Center, Duke University, Durham, NC, USA. aahuggins@arizona.edu.ORCID 0000-0001-7936-2116
C Lexi BairdBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.ORCID 0000-0002-1117-970X
Melvin BriggsBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Sarah LaskowitzBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Ahmed HussainBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.ORCID 0009-0005-8761-7525
Samar FoudaBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Courtney HaswellBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Delin SunBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Lauren E SalminenImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Neda JahanshadImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Sophia I ThomopoulosImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Dick J VeltmanAmsterdam UMC Vrije Universiteit, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Jessie L FrijlingAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Miranda OlffAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.ORCID 0000-0003-1016-9515
Mirjam van ZuidenAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Saskia B J KochAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Laura NawjinAmsterdam UMC Vrije Universiteit, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.ORCID 0000-0001-7183-8933
Li WangLaboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-1459-3412
Ye ZhuLaboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Gen LiLaboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Dan J SteinSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-7218-7810
Jonathan IpserSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Soraya SeedatDepartment of Psychiatry, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-5118-786X
Stefan du PlessisDepartment of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Leigh L van den HeuvelDepartment of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Benjamin Suarez-JimenezDepartment of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.
Xi ZhuDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0002-9724-7231
Yoojean KimNew York State Psychiatric Institute, New York, NY, USA.
Xiaofu HeDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Sigal Zilcha-ManoUniversity of Haifa, Haifa, Israel.ORCID 0000-0002-5645-4429
Amit LazarovDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0002-2811-2739
Yuval NeriaDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0003-4674-0314
Kerry J ResslerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-5158-1103
Tanja JovanovicDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-0160-7248
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-7720-252X
Anna R HudsonDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.ORCID 0000-0002-5752-7888
Sven C MuellerDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.ORCID 0000-0003-1661-3840
Anika SierkUniversity Medical Centre Charité, Berlin, Germany.ORCID 0000-0002-1396-8075
Antje MantheyUniversity Medical Centre Charité, Berlin, Germany.
Henrik WalterUniversity Medical Centre Charité, Berlin, Germany.ORCID 0000-0002-9403-6121
Judith K DanielsDepartment of Clinical Psychology, University of Groningen, Groningen, The Netherlands.
Christian SchmahlDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Julia I HerzogDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.ORCID 0000-0001-8326-5466
Pavel ŘíhaFirst Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0002-1322-2038
Ivan RektorCEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic.ORCID 0000-0002-9635-7404
Lauren A M LeboisDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5816-9181
Milissa L KaufmanDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Elizabeth A OlsonDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Justin T BakerDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6629-2195
Isabelle M RossoDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Anthony P KingDepartment of Psychiatry and Behavioral Health, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA.
Isreal LiberzonDepartment of Psychiatry, Texas A&M University, Bryan, Texas, USA.ORCID 0000-0002-4990-556X
Mike AngstadtDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-4870-7649
Nicholas D DavenportMinneapolis VA Health Care System, Minneapolis, MN, USA.
Scott R SponheimMinneapolis VA Health Care System, Minneapolis, MN, USA.ORCID 0000-0002-2782-0856
Seth G DisnerMinneapolis VA Health Care System, Minneapolis, MN, USA.ORCID 0000-0003-3635-9421
Thomas StraubeInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
David HofmannInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
Rongfeng QiDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.ORCID 0000-0002-9981-9918
Guang Ming LuDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.ORCID 0000-0003-4913-2314
Lee A BaughDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Gina L ForsterDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Raluca M SimonsCenter for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA.
Jeffrey S SimonsSioux Falls VA Health Care System, Sioux Falls, SD, USA.
Vincent A MagnottaDepartments of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-8639-5354
Kelene A FerchoDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Adi Maron-KatzDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Amit EtkinDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Andrew S CottonDepartment of Psychiatry, University of Toledo, Toledo, OH, USA.
Erin N O'LearyDepartment of Psychiatry, University of Toledo, Toledo, OH, USA.ORCID 0000-0002-2993-7003
Hong XieDepartment of Neurosciences, University of Toledo, Toledo, OH, USA.ORCID 0000-0002-5762-6456
Xin WangDepartment of Psychiatry, University of Toledo, Toledo, OH, USA.ORCID 0000-0003-1524-2902
Yann QuidéSchool of Psychology, University of New South Wales (UNSW) Sydney, Sydney, NSW, Australia.ORCID 0000-0002-8569-7139
Wissam El-HageUMR1253, Université de Tours, Inserm, Tours, France.
Shmuel LissekDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Hannah BergDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Steven BruceDepartment of Psychological Sciences, Center for Trauma Recovery University of Missouri-St. Louis, St. Louis, MO, USA.ORCID 0000-0002-5807-4382
Josh CislerDepartment of Psychiatry, University of Texas at Austin, Austin, TX, USA.
Marisa RossNorthwestern Neighborhood and Network Initiative, Northwestern University Institute for Policy Research, Evanston, IL, USA.
Ryan J HerringaSchool of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA.ORCID 0000-0002-1936-7959
Daniel W GrupeCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-4927-7572
Jack B NitschkeDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Richard J DavidsonCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-8506-4964
Christine L LarsonDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Terri A deRoon-CassiniDivision of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-9485-0625
Carissa W TomasComprehensive Injury Center, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-9199-8632
Jacklynn M FitzgeraldDepartment of Psychology, Marquette University, Milwaukee, WI, USA.
Jennifer Urbano BlackfordMunroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-0261-4845
Bunmi O OlatunjiDepartment of Psychology, Vanderbilt University, Nashville, TN, USA.
William S KremenDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-8629-5609
Michael J LyonsDept. of Psychological & Brain Sciences, Boston University, Boston, MA, USA.
Carol E FranzDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-8987-1755
Evan M GordonDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-2276-5237
Geoffrey MayVeterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.
Steven M NelsonDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Chadi G AbdallahDepartment of Psychiatry, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-5783-6181
Ifat LevyDepartments of Comparative Medicine, Neuroscience and Psychology, Wu Tsai Institute, Yale University, New Haven, CT, USA.ORCID 0000-0001-7851-9070
Ilan Harpaz-RotemDivision of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA.ORCID 0000-0002-6066-9406
John H KrystalDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6952-1726
Emily L DennisDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID 0000-0001-7112-4009
David F TateDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID 0000-0003-0213-1920
David X CifuDepartment of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA.
William C WalkerDepartment of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA.
Elizabeth A WildeDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Ian H HardingDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Vic, Australia.
Rebecca KerestesDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Vic, Australia.
Paul M ThompsonImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Rajendra MoreyBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Duke University · USHarvard University · USUniversity of Minnesota · USSouth African Medical Research Council · ZAEmory University · USImaging Center · USUniversity of South Dakota · USUniversity of Toledo · USUniversity of Wisconsin–Madison · USAmsterdam Neuroscience · NLCharité - Universitätsmedizin Berlin · DEChinese Academy of Sciences · CNColumbia University Irving Medical Center · USYale University · USBaylor College of Medicine · USCentral European Institute of Technology · CZGhent University Hospital · BEHeidelberg University · DEMedical College of Wisconsin · USNanjing General Hospital of Nanjing Military Command · CN

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SVAREN, JOHN P · 1985 to 2015
$25.2M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
X LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 1985 to 2007
$21.3M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2022
$14.1M
TRAINING PROGRAM IN EMOTION RESEARCHT32MH018931 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Richard J Davidson · 1989 to 2026
$11.6M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Neural Substrates of Affective Style and Emotion RegulationR01MH043454 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J, SCHAEFER, STACEY M · 1989 to 2022
$9.6M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
Genetic and Trauma-Related Risk Factors for PTSDR01MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2005 to 2014
$8.5M
Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) 27040CSRD VA I01 CX001135CSRD VA I01 CX001246CSRD VA I01 CX001820CSRD VA I01 CX002096CSRD VA I01 CX002097CSRD VA IK2 CX001680Department of Health | National Health and Medical Research Council (NHMRC) 1184403Deutsche Forschungsgemeinschaft (German Research Foundation) DA 1222/4-1Deutsche Forschungsgemeinschaft (German Research Foundation) SFB/TRR 58: C06, C07Deutsche Forschungsgemeinschaft (German Research Foundation) WA 1539/8-2HSRD VA I01 HX003155Michael J. Fox Foundation for Parkinson's Research (Michael J. Fox Foundation) 14848National Natural Science Foundation of China (National Science Foundation of China) 20ZDA079National Natural Science Foundation of China (National Science Foundation of China) 31971020National Natural Science Foundation of China (National Science Foundation of China) U21A20364Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation) BK20221554NCATS NIH HHS UL1 TR000454NCRR NIH HHS M01 RR000039NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG059874NIA NIH HHS R01 AG064955NIA NIH HHS R01 AG076838NIA NIH HHS R56 AG058854NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NICHD NIH HHS K12 HD085850NICHD NIH HHS P30 HD003352NICHD NIH HHS R01 HD071982NIMH NIH HHS K01 MH118428NIMH NIH HHS K01 MH118467NIMH NIH HHS K01 MH122774NIMH NIH HHS K23 MH090366NIMH NIH HHS K23 MH101380NIMH NIH HHS R01 MH043454NIMH NIH HHS R01 MH071537NIMH NIH HHS R01 MH096987NIMH NIH HHS R01 MH105355NIMH NIH HHS R01 MH105535NIMH NIH HHS R01 MH106574NIMH NIH HHS R01 MH107382NIMH NIH HHS R01 MH110483NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH113574NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH119227NIMH NIH HHS R01 MH129832NIMH NIH HHS R21 MH098198NIMH NIH HHS R21 MH098212NIMH NIH HHS R21 MH102634NIMH NIH HHS R21 MH106998NIMH NIH HHS R21 MH112956NIMH NIH HHS R21 MH125277NIMH NIH HHS R56 MH071537NIMH NIH HHS T32 MH018931NINDS NIH HHS R61 NS120249RRD VA I01 RX000622RRD VA I01 RX001135RRD VA I01 RX001774RRD VA I01 RX001880RRD VA I01 RX002076RRD VA I01 RX002170RRD VA I01 RX002171RRD VA I01 RX002172RRD VA I01 RX002173RRD VA I01 RX002174RRD VA I01 RX003442RRD VA I01 RX003443RRD VA I01 RX003444RRD VA IK2 RX000709RRD VA IK2 RX002922United States Department of Defense | United States Army | Army Medical Command | Congressionally Directed Medical Research Programs (CDMRP) W81XWH-08-2-0038U.S. Department of Defense (United States Department of Defense) W81XWH-10-1-0925U.S. Department of Defense (United States Department of Defense) W81XWH-12-2-0012U.S. Department of Health & Human Services | National Institutes of Health (NIH) M01RR00039U.S. Department of Health & Human Services | National Institutes of Health (NIH) UL1TR000454U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD071982U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD085850U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K01MH118428U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K01MH118467U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K01MH122774U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K23MH090366U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) M01RR00039U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH071537U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH098212U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH101380U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH096987U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH105355U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH105535U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH106574U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH107382U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH110483U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH111671U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH117601U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH119227U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH098198U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH102634U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH106998U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH112956U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R61NS120249U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG022381U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG050595U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG059874U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) P50U.S. Department of Veterans Affairs (Department of Veterans Affairs) 1IK2CX001680U.S. Department of Veterans Affairs (Department of Veterans Affairs) 1IK2RX000709U.S. Department of Veterans Affairs (Department of Veterans Affairs) 1K2RX002922U.S. Department of Veterans Affairs (Department of Veterans Affairs) I01RX000622ZonMw (Netherlands Organisation for Health Research and Development) 40-00812-98-10041
6 · The paper itself

Abstract

Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p

Indexed as

CerebellumMagnetic Resonance ImagingStress Disorders, Post-TraumaticAdultDeep LearningFemaleGray MatterHumansMaleMiddle AgedOrgan SizeWhite Matter

Identifiers

PMID38195980
PMCPMC11153161
OpenAlexW4390706126

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.