ArticleMolecular psychiatry2024
Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study.
Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies.Frontiers in psychiatry · 2024Pooled it
- Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.Molecular psychiatry · 2026Article
- Cell-based polygenic risk scores predict clinical progression and prioritize network-based therapeutic targets in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Mapping Focal and Generalized Effects of Common Genetic Variants on Human Brain Structure.bioRxiv : the preprint server for biology · 2026Article
- The Effects of Antipsychotics on Two Month Cortical Thickness and Two Year Clinical Outcomes Among Populations at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2026Article
- Decoding Psychosis Risk: Neuroanatomical Correlates of the NAPLS-2 Calculator in the PRONIA Cohort.Schizophrenia bulletin · 2026Article
- Shared subcortical-default mode morphological dysconnectivity in adolescent bipolar disorder, major depressive disorder and schizophrenia.Communications biology · 2026Article
- Distinct brain volume abnormalities in clinical high-risk individuals: pre- and post-antipsychotic treatment.Psychological medicine · 2026Article
- Deciphering the Heterogeneity of Schizophrenia: A Multimodal and Multivariate Neuroimaging Framework for Unveiling Brain-Symptom Relationships and Underlying Subtypes.Schizophrenia bulletin · 2026Article
- Neuroanatomical correlates of psychiatric manifestations in Wilson disease: the role of age.Frontiers in psychiatry · 2026Article
- Interaction between Neighborhood Exposome and Genetic Risk in Child Persistent Distressing Psychotic-like Experiences.Nature. Mental health · 2026Article
- Molecular Signatures of Early-Onset Bipolar Disorder and Schizophrenia: Transcriptomic and Machine-Learning Insights into Calcium and cAMP Signaling, Including Sex-Specific Patterns.International journal of molecular sciences · 2025Article
- Obstetric complications, cortical gyrification, and cognition in first-episode psychosis.Psychological medicine · 2025Article
- Microstructural imaging of brain changes in schizophrenia via quantitative T1 (qT1): a preliminary comparison of two acquisition protocols.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Reduced Cerebellar Volumes Associate with P300 Amplitude Attenuation in Children with Clinical High Risk for Psychosis and Early Onset Psychosis.Cerebellum (London, England) · 2025Article
- Macro- and Microstructural Alterations in the Midbrain in Early Psychosis Associates with Clinical Symptom Scores.eNeuro · 2025Article
- Examining neuroanatomical correlates of win-stay, lose-shift behaviour.Brain structure & function · 2025Article
- The Psychosis MRI Shared Data Resource (Psy-ShareD).Human brain mapping · 2025Article
- Association between fasting blood glucose and psychotic symptoms in Chinese patients with first-episode drug-naïve major depressive disorder.BMC psychiatry · 2025Article
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Authors and funding
45 authors at 20 institutions in 11 countries.
Funding
Abstract
introductionRegional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but previous studies have yielded conflicting results, likely due to small sample sizes and the different brain regions examined. In this study, we conducted a whole brain voxel-based morphometry (VBM) analysis in a large sample of individuals with EOP, using the newly developed ENIGMA-VBM tool.
methods15 independent cohorts from the ENIGMA-EOP working group participated in the study. The overall sample comprised T1-weighted MRI data from 482 individuals with EOP and 469 healthy controls. Each site performed the VBM analysis locally using the standardized ENIGMA-VBM tool. Statistical parametric T-maps were generated from each cohort and meta-analyzed to reveal voxel-wise differences between EOP and healthy controls as well as the individual-based association between GM volume and age of onset, chlorpromazine (CPZ) equivalent dose, and other clinical variables.
resultsCompared with healthy controls, individuals with EOP showed widespread lower GM volume encompassing most of the cortex, with the most marked effect in the left median cingulate (Hedges' g = 0.55, p = 0.001 corrected), as well as small clusters of lower white matter (WM), whereas no regional GM or WM volumes were higher in EOP. Lower GM volume in the cerebellum, thalamus and left inferior parietal gyrus was associated with older age of onset. Deficits in GM in the left inferior frontal gyrus, right insula, right precentral gyrus and right superior frontal gyrus were also associated with higher CPZ equivalent doses.
conclusionEOP is associated with widespread reductions in cortical GM volume, while WM is affected to a smaller extent. GM volume alterations are associated with age of onset and CPZ equivalent dose but these effects are small compared to case-control differences. Mapping anatomical abnormalities in EOP may lead to a better understanding of the role of psychosis in brain development during childhood and adolescence.
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