Trial reportJournal of perinatology : official journal of the California Perinatal Association2024
Time to regain birthweight and association with neurodevelopmental outcomes among extremely preterm newborns.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01378273 (Preterm Erythropoietin Neuroprotection Trial), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preterm Erythropoietin Neuroprotection Trial (PENUT Trial)
Who cites it
4 citing papers in PubMed.
- Gregory Valentine: ECI biocommentary.Pediatric research · 2026Article
- Evaluation of First-Week Fluid Intake and Maximal Weight Loss Percentage with In-Hospital Adverse Outcomes Among Moderately and Very Preterm Newborns in Ethiopia.Children (Basel, Switzerland) · 2025Article
- Postnatal Growth Assessment of the Very-Low-Birth-Weight Preterm Infant.Children (Basel, Switzerland) · 2025Review
- Revolutionizing Neonatal Nutrition: Rethinking Definitions and Standards for Optimal Care.Advances in nutrition (Bethesda, Md.) · 2024Article
Corrections and comments
- Update of
Authors and funding
11 authors.
Funding
Abstract
objectiveDetermine association between time to regain birthweight and 2-year neurodevelopment among extremely preterm (EP) newborns. STUDY
designSecondary analysis of the Preterm Erythropoietin Neuroprotection Trial evaluating time to regain birthweight, time from birth to weight nadir, time from nadir to regain birthweight, and cumulative weight loss with 2-year corrected Bayley Scales of Infant and Toddler Development 3rd edition.
resultsAmong n = 654 EP neonates, those with shorter nadir-to-regain had lower cognitive scores (≤1 day versus ≥8 days: -5.0 points, [CI -9.5, -0.6]) and lower motor scores (≤1 day versus ≥8 days: -4.6 points [CI -9.2, -0.03]) in adjusted stepwise forward regression modeling. Increasingly cumulative weight loss was associated with lower cognitive scores (≤-50 percent-days: -5.6, [CI -9.4, -1.8]), motor scores (≤-50 percent-days: -4.2, [CI -8.2, -0.2]); and language scores (≤-50 percent-days: -6.0, [CI -10.1, -1.9]).
conclusionFaster nadir-to-regain and excessive cumulative weight loss are associated with adverse 2-year neurodevelopmental outcomes.
trial registrationPENUT Trial Registration: NCT01378273. https://clinicaltrials.gov/ct2/show/NCT01378273 . CLINICAL
trial registrationThis study is a post-hoc secondary analysis of pre-existing data from the PENUT Trial (NCT #01378273).
Indexed as
Identifiers
38195922What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.