ArticleBMC medicine2024
Trajectories of health conditions and their associations with the risk of cognitive impairment among older adults: insights from a national prospective cohort study.
Article in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 31 citations in OpenAlex.
- Multinational cohort study of health perception mismatch trajectories and risks of cognitive decline, depression, and mortality.BMC public health · 2026Article
- Immune cell subsets linking insomnia trajectories and incident cognitive impairment: a prospective cohort study.BMC medicine · 2026Article
- A body shape index trajectories and cognitive function among older hypertensive patients: a national cohort study.Archives of public health = Archives belges de sante publique · 2026Article
- Associations of childhood economic and psychosocial conditions with later-life cognitive function: a longitudinal analysis of the China health and retirement longitudinal study (2011-2020).BMC public health · 2026Article
- Development of a clinical nomogram to assess the risk of cognitive impairment in community-dwelling middle-aged and older adults.BMC neurology · 2026Article
- Association between frailty and cognitive function in hospitalized older adults: a moderated serial mediation analysis involving functional status, depression, and social support.Frontiers in public health · 2026Article
- Cognitive impairment and depressive symptoms to predict renal outcome and mortality in older adult patients.PloS one · 2026Article
- Social alienation and cognitive function among older adults: the mediating roles of ruminative thinking and self-neglect.Frontiers in public health · 2026Article
- Vision impairment and cognitive function in Chinese older adults with diabetes: multiple mediating effects of social participation and perceived control.Frontiers in public health · 2026Article
- Association between multimorbidity and young-onset dementia: a prospective study.BMC public health · 2025Article
- Longitudinal associations between multimodal symptom clusters and functional disability in older adults: a comparative cohort analysis using SHARE, ELSA, and KLoSA.Scientific reports · 2025Article
- Latent Profiles Based on Combined Risk Factors for Cognitive Decline in European Older Adults: A Retrospective Study Based on the SHARE HCAP Project.Neurology international · 2025Article
- Association of longitudinal blood urea nitrogen trajectory with in-hospital and 28-day mortality in acute heart failure with cardiorenal syndrome.European journal of medical research · 2025Article
- Burden of multimorbidity and verbal phonemic fluency in cognitively healthy and mildly impaired older adults: findings from a real-world study.Aging clinical and experimental research · 2025Article
- IADL for identifying cognitive impairment in Chinese older adults: insights from cross-lagged panel network analysis.BMC geriatrics · 2025Article
- The association between stereoscopic vision and cognitive function on community-dwelling older adults: a cross-sectional study.BMC geriatrics · 2025Article
- Trajectories of health status and their association with rheumatoid arthritis risk: insights from a national prospective cohort study.BMC public health · 2025Article
- Longitudinal patterns of cognitive function and depression: insights from the China Health and Retirement Longitudinal Study.Journal of global health · 2025Article
- Cognitive function differs across healthy lifestyle behavior profiles: a 10-year population-based prospective cohort study.The journal of nutrition, health & aging · 2025Article
- Sleep trajectories and osteoporosis incidence: findings from two prospective cohort studies.Frontiers in public health · 2025Article
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Authors and funding
4 authors at 1 institution in 3 countries.
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Abstract
backgroundThe associations between trajectories of different health conditions and cognitive impairment among older adults were unknown. Our cohort study aimed to investigate the impact of various trajectories, including sleep disturbances, depressive symptoms, functional limitations, and multimorbidity, on the subsequent risk of cognitive impairment.
methodsWe conducted a prospective cohort study by using eight waves of national data from the Health and Retirement Study (HRS 2002-2018), involving 4319 adults aged 60 years or older in the USA. Sleep disturbances and depressive symptoms were measured using the Jenkins Sleep Scale and the Centers for Epidemiologic Research Depression (CES-D) scale, respectively. Functional limitations were assessed using activities of daily living (ADLs) and instrumental activities of daily living (IADLs), respectively. Multimorbidity status was assessed by self-reporting physician-diagnosed diseases. We identified 8-year trajectories at four examinations from 2002 to 2010 using latent class trajectory modeling. We screened participants for cognitive impairment using the 27-point HRS cognitive scale from 2010 to 2018 across four subsequent waves. We calculated hazard ratios (HR) using Cox proportional hazard models.
resultsDuring 25,914 person-years, 1230 participants developed cognitive impairment. In the fully adjusted model 3, the trajectories of sleep disturbances and ADLs limitations were not associated with the risk of cognitive impairment. Compared to the low trajectory, we found that the increasing trajectory of depressive symptoms (HR = 1.39; 95% CI = 1.17-1.65), the increasing trajectory of IADLs limitations (HR = 1.88; 95% CI = 1.43-2.46), and the high trajectory of multimorbidity status (HR = 1.48; 95% CI = 1.16-1.88) all posed an elevated risk of cognitive impairment. The increasing trajectory of IADLs limitations was associated with a higher risk of cognitive impairment among older adults living in urban areas (HR = 2.30; 95% CI = 1.65-3.21) and those who smoked (HR = 2.77; 95% CI = 1.91-4.02) (all P for interaction < 0.05).
conclusionsThe results suggest that tracking trajectories of depressive symptoms, instrumental functioning limitations, and multimorbidity status may be a potential and feasible screening method for identifying older adults at risk of cognitive impairment.
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