SynthesisBMC oral health2024
White spot lesions: diagnosis and treatment - a systematic review.
Synthesis in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Bioactive inorganic materials in dental resin infiltrants: a systematic and critical review of their effects on infiltrant properties and tooth surfaces.Clinical oral investigations · 2025Pooled it
- Toxicity of resin-matrix composites in a dental clinical setting.Odontology · 2025Pooled it
- Comparative assessment of four treatments for post orthodontic white spot lesions over a 24-month period: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Antibacterial and physicochemical properties of a zinc oxide nanoparticle-modified orthodontic adhesive : An in vitro study.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026Article
- Methodological Heterogeneity in Profilometric Assessment of Experimentally Demineralized Enamel as a Model of White Spot Lesions: A Systematic Review.Journal of functional biomaterials · 2026Review
- Effects of Additive Incorporation on Fluoride Release of Orthodontic Glass Ionomer Cements and Adhesives: A Systematic Review.Materials (Basel, Switzerland) · 2026Review
- Article
- Remineralization of Artificial Caries-like Lesions in Permanent Enamel by MI Paste One: Comparative Physicochemical Outcomes and In Vitro Resistance to Secondary Demineralization.Journal of functional biomaterials · 2026Article
- Investigation of enamel surface changes in teeth with artificially produced white spot lesions after debonding: an in vitro study.BMC oral health · 2026Article
- Tooth Enamel Demineralization: Caries and Erosion from the Viewpoint of Chemistry.Dentistry journal · 2026Review
- Incidence and distribution of white spot lesions after clear aligner versus fixed appliance therapy : A retrospective digital photograph and intraoral scan analysis.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026Article
- Chicken eggshell paste versus CPP-ACP for enamel remineralization: a pilot in vitro study using micro-computed tomography.The Saudi dental journal · 2026Article
- Optimization of In Vitro White Spot Lesion Protocol: Comparative Diagnostics via Visual Inspection, Scanning Electron Microscopy, and Fluorescence Methods.Diagnostics (Basel, Switzerland) · 2026Article
- Chitosan-arginine/amorphous calcium phosphate nanoparticles-containing orthodontic cement: antibacterial and remineralization strategies against enamel white spot lesions.BMC oral health · 2026Article
- Addressing Research Gaps in Early Childhood Caries: A Comprehensive Review.Dentistry journal · 2026Review
- Fish bone and chitosan based nanogels in green dentistry: sustainable and eco-friendly biomimetic remineralizing agents for early enamel caries.BMC oral health · 2026Article
- Influence of White Spot Lesion Severity on the Structural, Optical, and Mechanical Outcomes of Resin Infiltration: An In Vitro Study.Diagnostics (Basel, Switzerland) · 2026Article
- Cariogenic Enamel Demineralization Prevention, Detection, and Management: A Literature Review.European journal of dentistry · 2026Article
- Prevalence of white spot lesions in children and adolescents across Northern, Central and Southern Italy: a multicenter cross-sectional study.Frontiers in oral health · 2026Article
- CaAm-P19: a novel amelogenin-derived peptide for enamel remineralization.Regenerative biomaterials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhite spot lesions represent the first stage of caries and their prevalence has been increasing in recent years, particularly in patients undergoing orthodontic treatment. DIferential diagnosis and lesion activity are essential to decide on the clinical approaches to treatment. The aim of this study is to understand if the new diagnostic tools such as fluorescence, microradiography and computed microtomography have the potential to change the conventional treatment of white spots".
methodsA systematic search of available studies in the literature was carried out, using PRISMA guidelines, in Pubmed and Scopus electronic databases and manually to identify relevant articles to answer the PICO question: "Do the new diagnostic tools have the potential to change the conventional treatment of white spots?". This systematic review included randomized controlled trials (RCT), cross-sectional and longitudinal studies complying with the following inclusion criteria: (i) studies in humans, (ii) studies about white spot lesions, (iii) studies published between 2012 and 2023, (iv) studies having both diagnosis and treatment and (v) studies with full text available. In this review we excluded other systematic reviews of clinical trials and in vitro studies. The RoB tool was used to assess the risk of bias.
resultsThe systematic literature search identified 143 potentially relevant references, which after applying the exclusion criteria, resulted in 20 articles. Regarding diagnostic methods, most articles found were based on conventional methods of visual examination (n:10) or fluorescence (n:7). The least referenced diagnostic techniques were based on the use of clinical photographs (n:2), cross-sectional microradiography (n:1) and computed microtomography (n:1). The use of DIAGNOdent was reported by 3 in vitro studies. With regard to therapies, most studies reported the use of infiltrating resin (n:7) and fluoride-based products (n:5). Other studies have reported the use of self-assembling peptide P11-4 (n:1), home care (n:1), casein phosphopeptide-amorphous calcium phosphate (n:2) and hydrochloric acid (n:1). Combination therapies were also considered.
conclusionDiagnostic tool does not have the potential to change the form of treatment, whether it is a conventional method or a more differentiated one.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.