Evidence map›Paper›PMID 38195109›Full record

ArticleZeitschrift fur Gastroenterologie2024

Living-Donor Liver Transplantation for a Large Hepatocellular Carcinoma in a Genetically Identical Twin Sister.

Ger Koek, Sophia M Schmitz, Jan Bednarsch, Daniel Heise, Thomas Longerich, Frank Bakers, Christian Trautwein, Tom Luedde, Tom Florian Ulmer, Ulf Peter Neumann

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Zeitschrift fur Gastroenterologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Ger KoekDepartment of Internal Medicine, Division of Gastroenterology/Hepatology, Maastricht UMC+, Maastricht, Netherlands.
Sophia M SchmitzGeneral-, Visceral and Transplantation Surgery, Universitätsklinikum Essen, Essen, Germany.ORCID 0000-0001-6732-1595
Jan BednarschGeneral-, Visceral and Transplantation Surgery, Universitätsklinikum Essen, Essen, Germany.
Daniel HeiseGeneral-, Visceral and Transplantation Surgery, Universitätsklinikum Essen, Essen, Germany.
Thomas LongerichInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Frank BakersDepartment of Radiology, Maastricht UMC+, Maastricht, Netherlands.
Christian TrautweinDepartment of Gastroenterology Metabolic Disorders and Internal Intensive Medicine, University Hospital RWTH Aachen, Aachen, Germany.
Tom LueddeDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Duesseldorf, Germany.ORCID 0000-0002-6288-8821
Tom Florian UlmerGeneral-, Visceral and Transplantation Surgery, Universitätsklinikum Essen, Essen, Germany.
Ulf Peter NeumannGeneral-, Visceral and Transplantation Surgery, Universitätsklinikum Essen, Essen, Germany.
Maastricht University Medical Centre · NLEssen University Hospital · DEDüsseldorf University Hospital · DEHeidelberg University · DERWTH Aachen University · DE

Funding

TKI-LSH 40-41200-98-9306
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is, to date, the most common malignant tumor of the liver and is commonly staged with the Milan criteria. While deceased-donor liver transplantations (DDLT) are reserved for patients within the Milan criteria, living-donor liver transplantation (LDLT) might be a curative option for patients outside the Milan criteria. We here report a case of a 32-year-old woman who developed a giant, unresectable HCC out of a hepatocellular adenoma (HCA) after a pregnancy. The genetically identical twin sister donated her left hemi-liver after ethical approval and preoperative screening. No long-term immunosuppressive therapy was necessary, and after more than eight years, both are in perfect health and the recipient gave birth to a second child. This case shows that in certain situations large HCCs outside the standard criteria can be cured by LT. Careful evaluation of both donor and recipient should be performed for indications like this to assure optimal clinical outcome.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsLiver TransplantationAdultFemaleHumansLiving DonorsTwins, Monozygotic

Identifiers

PMID38195109
PMCPMC10783995
OpenAlexW4390777464

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.