ArticleZeitschrift fur Gastroenterologie2024
Liver transplantation for HCC in cirrhosis: Are Milan criteria outdated?
Article in Zeitschrift fur Gastroenterologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Arterial Complications in Patients Undergoing Liver Transplantation After Previous TACE Treatment.Journal of clinical medicine · 2025Article
- Does depressurization of the portal vein before liver transplantation affect the recurrence of HCC? A nested case-control study.BMC cancer · 2024Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
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Abstract
In Germany, organ allocation is based on the MELD-system and lab-MELD is usually low in patients with hepatocellular carcinoma (HCC) in cirrhosis. Higher medical urgency can be achieved by standard exception for HCC (SE-HCC), if Milan criteria (MC) are met. Noteworthy, UNOS T2 reflects MC, but excludes singular lesions < 2 cm. Thus, SE-HCC is awarded to patients with one lesion between 2 and 5 cm or 2 to 3 lesions between 1 and 3 cm. These criteria are static and do not reflect biological properties of HCC.We present a retrospective cohort of 111 patients, who underwent liver transplantation at UKSH, Campus Kiel between 2007 and 2017. No difference was found in overall survival for patient cohorts using Milan, UCSF, up-to-seven, and French-AFP criteria. However, there was a significantly reduced survival, if microvascular invasion was detected in the explanted organ and in patients with HCC-recurrence. The exclusive use of static selection criteria including MC appear to limit the access to liver transplantation.
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